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Tbio
PLXNB3
Plexin-B3

Protein Summary
Description
Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. The protein encoded by this gene is a member of the plexin family. It functions as a receptor for semaphorin 5A, and plays a role in axon guidance, invasive growth and cell migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361971
  • ENSP00000355378
  • ENSG00000198753
  • ENST00000538966
  • ENSP00000442736

Symbol
  • KIAA1206
  • PLXN6
  • PLEXR
  • PLXN6
  • PLEXB3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
small molecule perturbation
0.58
cell type or tissue
0.55
biological process
0.49
cell line
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.89   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 80   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.89   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (90)
SEMA4D
Tbio
Novelty:  0.0043592
Score:  0.965
Data Source:  STRINGDB
SEMA5A
Tbio
Novelty:  0.00885528
Score:  0.961
Data Source:  Reactome,STRINGDB
SEMA4F
Tbio
Novelty:  0.00574057
Score:  0.955
Data Source:  STRINGDB
SEMA6D
Tbio
Novelty:  0.01322475
Score:  0.944
Data Source:  STRINGDB
SEMA6C
Tbio
Novelty:  0.01557334
Score:  0.937
Data Source:  STRINGDB
RND1
Tbio
Family:  Enzyme
Novelty:  0.00834946
Score:  0.929
Data Source:  STRINGDB
SEMA3B
Tbio
Novelty:  0.00626976
Score:  0.926
Data Source:  STRINGDB
SEMA3F
Tbio
Novelty:  0.00676786
Score:  0.92
Data Source:  STRINGDB
SEMA3G
Tbio
Novelty:  0.0107653
Score:  0.918
Data Source:  STRINGDB
SEMA3C
Tbio
Novelty:  0.00828813
Score:  0.915
Data Source:  STRINGDB
Pathways (5)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Other semaphorin interactions
Reactome
Semaphorin interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Other semaphorin interactions
Semaphorin interactions
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
1
1
1
40.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
1
40.4
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
plexin B3
696903
Mouse
MGI:2154240
140571
Rat
RGD:1560615
363517
Dog
plexin B3
VGNC:44724
492243
Horse
plexin B3
VGNC:21605
100058942
Species
Name
OMA
EggNOG
Inparanoid
Macaque
plexin B3
Mouse
Rat
Dog
plexin B3
Horse
plexin B3
Publication Statistics
PubMed Score 23.89
PubMed score by year
PubTator Score 10.15
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title