Protein Summary
Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).
- ENST00000321063
- ENSP00000323194
- ENSG00000221866
- ENST00000359827
- ENSP00000352882
- ENST00000378539
- ENSP00000367800
- ENST00000423507
- ENSP00000392772
- KIAA1550
- PLXNA4A
- PLXNA4B
- PLEXA4
- PLXNA4A
- PLXNA4B
- FAYV2820
- PRO34003
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 0.99 | ||
trait | 0.97 | ||
microRNA | 0.82 | ||
phenotype | 0.73 | ||
transcription factor | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 58.42 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 182 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 58.42 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 182 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0