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Tbio
PLXNA3
Plexin-A3

Protein Summary
Description
Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as apoptosis. Studies of a similar gene in zebrafish suggest that it is important for axon pathfinding in the develop ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369682
  • ENSP00000358696
  • ENSG00000130827

Symbol
  • PLXN4
  • SEX
  • 6.3
  • PLXN3
  • PLXN4
  • XAP-6
  • HSSEXGENE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
biological process
0.72
cell type or tissue
0.71
histone modification site profile
0.63
co-expressed gene
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.37   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 44   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.37   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (108)
SCGB1D1
Tbio
Novelty:  0.04199997
p_int:  0.977454211
p_ni:  0.022545789
Data Source:  BioPlex
SCGB2A1
Tbio
Novelty:  0.01902973
p_int:  0.965401719
p_ni:  0.034598281
Data Source:  BioPlex
SCGB2A2
Tbio
Novelty:  0.01594053
p_int:  0.962233991
p_ni:  0.037766009
Data Source:  BioPlex
CST9L
Tdark
Novelty:  0.21941207
p_int:  0.954562761
p_ni:  0.045437239
Data Source:  BioPlex
HLA-E
Tbio
Novelty:  0.00216583
p_int:  0.948615577
p_ni:  0.051384423
Score:  0.189
Data Source:  BioPlex,STRINGDB
EDDM3B
Tdark
Novelty:  0.12874735
p_int:  0.885412756
p_ni:  0.114587244
Data Source:  BioPlex
HYOU1
Tbio
Novelty:  0.00833649
p_int:  0.879134226
p_ni:  0.120865774
Data Source:  BioPlex
CA6
Tclin
Family:  Enzyme
Novelty:  0.00293722
p_int:  0.831823608
p_ni:  0.168176392
Data Source:  BioPlex
INS
Tbio
Novelty:  0.00000499
p_int:  0.793528071
p_ni:  0.206471929
Data Source:  BioPlex
LYPD2
Tdark
Novelty:  0.55307434
p_int:  0.780266408
p_ni:  0.219733592
Data Source:  BioPlex
Pathways (7)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
CRMPs in Sema3A signaling
Reactome
Developmental Biology
Reactome
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Reactome
Sema3A PAK dependent Axon repulsion
Name
Explore in Pharos
Explore in Source
Axon guidance
CRMPs in Sema3A signaling
Developmental Biology
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Sema3A PAK dependent Axon repulsion
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
3
1
3
95.6
red blood cell distribution width
1
1
1
89.7
hemolysis
1
1
0
3.8
80.1
erythrocyte count
1
1
1
79.4
hematocrit
1
1
1
77.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
3
95.6
red blood cell distribution width
1
89.7
hemolysis
0
3.8
80.1
erythrocyte count
1
79.4
hematocrit
1
77.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
plexin A3
700399
Mouse
MGI:107683
18846
Rat
RGD:1584973
309280
Horse
plexin A3
VGNC:21602
100058349
Opossum
plexin A3
100022530
Species
Name
OMA
EggNOG
Inparanoid
Macaque
plexin A3
Mouse
Rat
Horse
plexin A3
Opossum
plexin A3
Publication Statistics
PubMed Score 52.37
PubMed score by year
PubTator Score 7.05
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title