Protein Summary
Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. [provided by RefSeq, ...more
- ENST00000367033
- ENSP00000356000
- ENSG00000076356
- KIAA0463
- OCT
- PLXN2
- OCT
- PLXN2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.99 | ||
transcription factor perturbation | 0.98 | ||
transcription factor binding site profile | 0.85 | ||
kinase perturbation | 0.81 | ||
PubMedID | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 51.89 (req: < 5)
Gene RIFs: 20 (req: <= 3)
Antibodies: 171 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 51.89 (req: >= 5)
Gene RIFs: 20 (req: > 3)
Antibodies: 171 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (155)
LACRT
Novelty: 0.03333799
p_int: 0.999967747
p_ni: 0.000032253
Score: 0.166
Data Source: BioPlex,STRINGDB
ST8SIA4
Family: Enzyme
Novelty: 0.00338436
p_int: 0.996137812
p_ni: 0.003862188
Data Source: BioPlex
PTPRK
Family: Enzyme
Novelty: 0.03149943
p_int: 0.993702629
p_ni: 0.006297367
p_wrong: 4e-9
Score: 0.184
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (3)
Upstream (1)
Downstream (2)
1 – 1 of 1
Pathways (10)
Reactome (7)
KEGG (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | CRMPs in Sema3A signaling | ||||
Reactome | Developmental Biology | ||||
Reactome | Other semaphorin interactions | ||||
Reactome | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
CRMPs in Sema3A signaling | ||||
Developmental Biology | ||||
Other semaphorin interactions | ||||
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (2)
Components (3)
Processes (13)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
adolescent idiopathic scoliosis | 2 | 1 | 0 | 1.2 | 15.8 | ||||
heart rate | 1 | 1 | 1 | 8.7 | |||||
risk-taking behaviour | 1 | 1 | 1 | 3.2 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
adolescent idiopathic scoliosis | 0 | 1.2 | 15.8 | ||||
heart rate | 1 | 8.7 | |||||
risk-taking behaviour | 1 | 3.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | plexin A2 | 713800 | ||||||
Mouse | MGI:107684 | 18845 | ||||||
Rat | RGD:1305325 | 289392 | ||||||
Dog | plexin A2 | VGNC:44719 | 490270 | |||||
Horse | plexin A2 | VGNC:21601 | 100051646 | |||||
Publication Statistics
PubMed Score 51.89
PubMed score by year
PubTator Score 2943.33
PubTator score by year
Related Publications
Text Mined References (36)
GeneRif Annotations (20)
Items per page:
0 of 0
PMID | Year | Title |
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