Protein Summary
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).
- ENST00000393409
- ENSP00000377061
- ENSG00000114554
- NOV
- PLXN1
- NOV
- NOVP
- PLXN1
- PLEXIN-A1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.99 | ||
virus perturbation | 0.83 | ||
protein complex | 0.81 | ||
transcription factor perturbation | 0.8 | ||
disease perturbation | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 77.54 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 163 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 77.54 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 163 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (136)
ST8SIA4
Family: Enzyme
Novelty: 0.00338436
p_int: 0.953357932
p_ni: 0.046642068
Data Source: BioPlex
LGALS9
Novelty: 0.00381766
p_int: 0.94231959
p_ni: 0.057680409
p_wrong: 1e-9
Data Source: BioPlex
MGAT4C
Family: Enzyme
Novelty: 0.19680806
p_int: 0.846781268
p_ni: 0.153218732
Score: 0.201
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (3)
Upstream (1)
Downstream (2)
1 – 1 of 1
Pathways (9)
Reactome (7)
KEGG (1)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | CRMPs in Sema3A signaling | ||||
Reactome | Developmental Biology | ||||
Reactome | Other semaphorin interactions | ||||
Reactome | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
CRMPs in Sema3A signaling | ||||
Developmental Biology | ||||
Other semaphorin interactions | ||||
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (2)
Components (4)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
platelet count | 1 | 1 | 1 | 42.3 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
platelet count | 1 | 42.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | plexin A1 | VGNC:2516 | 460665 | |||||
Macaque | plexin A1 | 716805 | ||||||
Mouse | MGI:107685 | 18844 | ||||||
Rat | RGD:1560871 | 362398 | ||||||
Dog | plexin A1 | VGNC:44718 | 100688869 | |||||
Publication Statistics
PubMed Score 77.54
PubMed score by year
PubTator Score 35.53
PubTator score by year
Related Publications
Text Mined References (34)
GeneRif Annotations (13)
Items per page:
0 of 0
PMID | Year | Title |
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