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Tbio
PLVAP
Plasmalemma vesicle-associated protein

Protein Summary
Description
Involved in the formation of stomatal and fenestral diaphragms of caveolae. May function in microvascular permeability.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252590
  • ENSP00000252590
  • ENSG00000130300

Symbol
  • FELS
  • PV1
  • PV1
  • FELS
  • PV-1
  • gp68
  • DIAR10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.65
phenotype
0.64
gene perturbation
0.58
tissue
0.58
cellular component
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.71   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 196   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.71   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 196   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (25)
ASGR1
Tbio
Novelty:  0.00209845
p_int:  0.999964967
p_ni:  0.000012305
p_wrong:  0.000022728
Score:  0.269
Data Source:  BioPlex,STRINGDB
ZDHHC6
Tbio
Family:  Enzyme
Novelty:  0.17384821
p_int:  0.999931778
p_ni:  0.000068222
Score:  0.234
Data Source:  BioPlex,STRINGDB
SMPD2
Tchem
Family:  Enzyme
Novelty:  0.00375744
p_int:  0.957479637
p_ni:  0.029863364
p_wrong:  0.012656998
Score:  0.198
Data Source:  BioPlex,STRINGDB
OSBPL11
Tbio
Novelty:  0.17706694
p_int:  0.951371328
p_ni:  0.048628665
p_wrong:  7e-9
Score:  0.219
Data Source:  BioPlex,STRINGDB
FUT8
Tbio
Family:  Enzyme
Novelty:  0.00675388
p_int:  0.900090962
p_ni:  0.099909038
Score:  0.177
Data Source:  BioPlex,STRINGDB
LMAN2L
Tbio
Novelty:  0.04364985
p_int:  0.83272566
p_ni:  0.16727434
Score:  0.534
Data Source:  BioPlex,STRINGDB
BST2
Tbio
Novelty:  0.00254359
Score:  0.752
Data Source:  STRINGDB
MZF1
Tbio
Family:  TF
Novelty:  0.01193919
Score:  0.711
Data Source:  STRINGDB
ZSCAN1
Tbio
Family:  TF
Novelty:  0.0217244
Score:  0.711
Data Source:  STRINGDB
VWF
Tclin
Novelty:  0.00009007
Score:  0.654
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
4
0
1.2
93.9
2
3
0
1.2
92.6
mitochondrial DNA measurement
2
3
3
90
3
2
0
1.1
83.4
ovarian serous carcinoma
2
1
0
1.2
77.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
93.9
0
1.2
92.6
mitochondrial DNA measurement
3
90
0
1.1
83.4
ovarian serous carcinoma
0
1.2
77.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
plasmalemma vesicle associated protein
VGNC:2283
455836
Macaque
plasmalemma vesicle associated protein
719830
Mouse
MGI:1890497
84094
Rat
RGD:619971
56765
Dog
plasmalemma vesicle associated protein
VGNC:44715
484837
Species
Name
OMA
EggNOG
Inparanoid
Chimp
plasmalemma vesicle associated protein
Macaque
plasmalemma vesicle associated protein
Mouse
Rat
Dog
plasmalemma vesicle associated protein
Publication Statistics
PubMed Score 82.71
PubMed score by year
PubTator Score 141.43
PubTator score by year
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Related Publications
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PMID
Year
Title