Tbio PLTP Phospholipid transfer protein

Protein Summary

Description

Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability. The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P55058
• A8K006
• B4DDD5
• B4DRB4
• E1P5N8
• E7EV16
• Q8WTT1
• Q9BR07
• Q9BSH8

Gene Name

• PLTP

Ensembl ID

• ENST00000354050
• ENSP00000335290
• ENSG00000100979
• ENST00000372420
• ENSP00000361497
• ENST00000372431
• ENSP00000361508
• ENST00000420868
• ENSP00000411671
• ENST00000477313
• ENSP00000417138

Symbol

• BPIFE
• HDLCQ9

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
metabolite	0.98
PubMedID	0.93
disease perturbation	0.83
gene perturbation	0.78
protein domain	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 456.69   (req: < 5)

Gene RIFs: 98   (req: <= 3)

Antibodies: 292   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 456.69   (req: >= 5)

Gene RIFs: 98   (req: > 3)

Antibodies: 292   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0