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Tbio
PLSCR1
Phospholipid scramblase 1

Protein Summary
Description
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342435
  • ENSP00000345494
  • ENSG00000188313
  • ENST00000448787
  • ENSP00000411675

Symbol
  • MMTRA1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
metabolite
0.98
PubMedID
0.96
transcription factor perturbation
0.96
molecular function
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.16   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 246   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.16   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (86)
RETREG3
Tdark
Novelty:  0.99215801
p_int:  0.999985566
p_ni:  0.000014052
p_wrong:  3.83e-7
Score:  0.19
Data Source:  BioPlex,STRINGDB
REEP1
Tbio
Novelty:  0.02280713
p_int:  0.999953375
p_ni:  0.000045553
p_wrong:  0.000001072
Score:  0.196
Data Source:  BioPlex,STRINGDB
RTN1
Tbio
Novelty:  0.01828064
p_int:  0.999943246
p_ni:  0.00004451
p_wrong:  0.000012243
Score:  0.579
Data Source:  BioPlex,STRINGDB
CLCC1
Tbio
Family:  IC
Novelty:  0.06584842
p_int:  0.999939215
p_ni:  0.000053575
p_wrong:  0.000007211
Score:  0.189
Data Source:  BioPlex,STRINGDB
BOLA1
Tbio
Novelty:  0.1092583
p_int:  0.999767419
p_ni:  0.000228383
p_wrong:  0.000004198
Score:  0.188
Data Source:  BioPlex,STRINGDB
REEP5
Tbio
Novelty:  0.00160455
p_int:  0.999745384
p_ni:  0.000254574
p_wrong:  4.2e-8
Score:  0.369
Data Source:  BioPlex,STRINGDB
C12orf49
Tdark
Novelty:  0.56030929
p_int:  0.999329688
p_ni:  0.000670302
p_wrong:  1.1e-8
Score:  0.165
Data Source:  BioPlex,STRINGDB
TMEM128
Tdark
Novelty:  5.15874803
p_int:  0.997070701
p_ni:  0.002814752
p_wrong:  0.000114547
Score:  0.542
Data Source:  BioPlex,STRINGDB
FAM8A1
Tbio
Novelty:  0.08206001
p_int:  0.995461135
p_ni:  0.000184039
p_wrong:  0.004354826
Data Source:  BioPlex
HRG
Tbio
Novelty:  0.0027048
p_int:  0.991188048
p_ni:  0.007756462
p_wrong:  0.00105549
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (34)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
1
1
1
0.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
1
0.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipid scramblase 1
VGNC:12125
460757
Macaque
phospholipid scramblase 1 [Source:RefSeq peptide;Acc:NP_001245006]
Mouse
MGI:893575
22038
Rat
Dog
phospholipid scramblase 1
611500
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipid scramblase 1
Macaque
phospholipid scramblase 1 [Source:RefSeq peptide;Acc:NP_001245006]
Mouse
Rat
Dog
phospholipid scramblase 1
Publication Statistics
PubMed Score 92.16
PubMed score by year
PubTator Score 62.27
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title