Tbio PLRG1 Pleiotropic regulator 1

Protein Summary

Description

Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:28076346). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (PubMed:11101529, PubMed:11544257). This gene encodes a core component of the cell division cycle 5-like (CDC5L) complex. The CDC5L complex is part of the spliceosome and is required for pre-mRNA splicing. The encoded protein plays a critical role in alternative splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Uniprot Accession IDs

• O43660
• B3KMK4
• Q3KQY5
• Q8WUD8

Gene Name

• PLRG1

Ensembl ID

• ENST00000302078
• ENSP00000303191
• ENSG00000171566
• ENST00000499023
• ENSP00000424417

Symbol

• Cwc1
• PRL1
• PRP46
• PRPF46
• TANGO4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
disease perturbation	0.83
histone modification site profile	0.82
kinase perturbation	0.81
transcription factor binding site profile	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.59   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 241   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.59   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (325)

Explore Interacting Targets

1 – 10 of 325

• See Interactions on String-DB

LINS1

Tbio

Novelty:  0.00317377

p_int:  0.999995365

p_ni:  6.7e-8

p_wrong:  0.000004568

Score:  0.416

Data Source:  BioPlex,STRINGDB

PRPF19

Tbio

Novelty:  0.01616737

p_int:  0.999975348

p_ni:  0.000024652

Score:  0.999

Data Source:  BioPlex,STRINGDB

CDC5L

Tbio

Family:  TF

Novelty:  0.00663599

p_int:  0.999686568

p_ni:  0.000313432

Score:  0.999

Data Source:  BioPlex,STRINGDB

XAB2

Tbio

Novelty:  0.04104647

p_int:  0.993286729

p_ni:  0.006713271

Score:  0.999

Data Source:  BioPlex,STRINGDB

CWF19L2

Tdark

Novelty:  0.80210985

p_int:  0.989285999

p_ni:  0.010714

p_wrong:  1e-9

Score:  0.889

Data Source:  BioPlex,STRINGDB

CRNKL1

Tbio

Novelty:  0.10274174

p_int:  0.9863086

p_ni:  0.0136914

Score:  0.999

Data Source:  BioPlex,STRINGDB

AQR

Tbio

Novelty:  0.00434312

p_int:  0.985728424

p_ni:  0.014271574

p_wrong:  2e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

DHX35

Tdark

Family:  Enzyme

Novelty:  0.26052594

p_int:  0.984863164

p_ni:  0.015136828

p_wrong:  8e-9

Score:  0.952

Data Source:  BioPlex,STRINGDB

GPATCH1

Tdark

Novelty:  0.93318176

p_int:  0.982581761

p_ni:  0.017418237

p_wrong:  2e-9

Score:  0.847

Data Source:  BioPlex,STRINGDB

ISY1

Tdark

Novelty:  1.68602768

p_int:  0.975796263

p_ni:  0.024203737

Score:  0.99

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (5)

Reactome (4)

KEGG (1)

Metabolism of RNA (R-HSA-8953854)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
Reactome	mRNA Splicing	188 targets	R-HSA-72172
Reactome	mRNA Splicing - Major Pathway	180 targets	R-HSA-72163

Name	Explore in Pharos	Explore in Source
Metabolism of RNA	686 targets	R-HSA-8953854
Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
mRNA Splicing	188 targets	R-HSA-72172
mRNA Splicing - Major Pathway	180 targets	R-HSA-72163

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (12)

Components (9)

Processes (3)

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1 – 9 of 9

GO Term	Evidence	Assigned by
catalytic step 2 spliceosome	Inferred from Direct Assay (IDA)	UniProtKB
fibrillar center	Inferred from Direct Assay (IDA)	HPA
nuclear membrane	Inferred from Direct Assay (IDA)	HPA
nuclear speck	Inferred from Direct Assay (IDA)	HPA
nucleus	Inferred from Direct Assay (IDA)	UniProtKB
U2-type catalytic step 2 spliceosome	Inferred from Direct Assay (IDA)	UniProtKB
Cul4-RING E3 ubiquitin ligase complex	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
Prp19 complex	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
nucleoplasm	Traceable Author Statement (TAS)	Reactome

Disease Associations (null)

No disease associations found

GWAS Traits (9)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
fibrinogen measurement	EFO_0004623	8	14	14	12.9	99.8
venous thromboembolism	EFO_0004286	7	5	2	1.2	98.2
low density lipoprotein cholesterol measurement	EFO_0004611	3	3	3		89.2
prothrombin time measurement	EFO_0008390	1	1	1		72.9
total cholesterol measurement	EFO_0004574	3	2	3		70.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
fibrinogen measurement	EFO_0004623	14	12.9	99.8
venous thromboembolism	EFO_0004286	2	1.2	98.2
low density lipoprotein cholesterol measurement	EFO_0004611	3		89.2
prothrombin time measurement	EFO_0008390	1		72.9
total cholesterol measurement	EFO_0004574	3		70.5

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
mRNA processing
mRNA splicing
Nucleus
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein B measurement
bilirubin measurement
fibrinogen measurement
glycine measurement
low density lipoprotein cholesterol measurement
partial thromboplastin time
prothrombin time measurement
total cholesterol measurement
venous thromboembolism

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
cellular phenotype
mortality/aging
muscle phenotype
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (16)

1 – 5 of 16

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	pleiotropic regulator 1	VGNC:669	461557
Macaque	pleiotropic regulator 1		701044
Mouse	pleiotropic regulator 1	MGI:1858197	53317
Rat	pleiotropic regulator 1	RGD:621047	60376
Dog	pleiotropic regulator 1	VGNC:44710	612490

Species	Name	OMA	EggNOG	Inparanoid
Chimp	pleiotropic regulator 1
Macaque	pleiotropic regulator 1
Mouse	pleiotropic regulator 1
Rat	pleiotropic regulator 1
Dog	pleiotropic regulator 1

Publication Statistics

PubMed Score 20.59

PubMed score by year

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PubTator Score 7.56

PubTator score by year

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Related Publications

Text Mined References (21)

GeneRif Annotations (4)

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PMID	Year	Title