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Tbio
PLRG1
Pleiotropic regulator 1

Protein Summary
Description
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:28076346). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (PubMed:11101529, PubMed:11544257). This gene encodes a core component of the cell division cycle 5-like (CDC5L) complex. The CDC5L complex is part of the spliceosome and is required for pre-mRNA splicing. The encoded protein plays a critical role in alternative splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302078
  • ENSP00000303191
  • ENSG00000171566
  • ENST00000499023
  • ENSP00000424417

Symbol
  • Cwc1
  • PRL1
  • PRP46
  • PRPF46
  • TANGO4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.83
histone modification site profile
0.82
kinase perturbation
0.81
transcription factor binding site profile
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.59   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 241   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.59   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (325)
LINS1
Tbio
Novelty:  0.00317377
p_int:  0.999995365
p_ni:  6.7e-8
p_wrong:  0.000004568
Score:  0.416
Data Source:  BioPlex,STRINGDB
PRPF19
Tbio
Novelty:  0.01616737
p_int:  0.999975348
p_ni:  0.000024652
Score:  0.999
Data Source:  BioPlex,STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
p_int:  0.999686568
p_ni:  0.000313432
Score:  0.999
Data Source:  BioPlex,STRINGDB
XAB2
Tbio
Novelty:  0.04104647
p_int:  0.993286729
p_ni:  0.006713271
Score:  0.999
Data Source:  BioPlex,STRINGDB
CWF19L2
Tdark
Novelty:  0.80210985
p_int:  0.989285999
p_ni:  0.010714
p_wrong:  1e-9
Score:  0.889
Data Source:  BioPlex,STRINGDB
CRNKL1
Tbio
Novelty:  0.10274174
p_int:  0.9863086
p_ni:  0.0136914
Score:  0.999
Data Source:  BioPlex,STRINGDB
AQR
Tbio
Novelty:  0.00434312
p_int:  0.985728424
p_ni:  0.014271574
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
DHX35
Tdark
Family:  Enzyme
Novelty:  0.26052594
p_int:  0.984863164
p_ni:  0.015136828
p_wrong:  8e-9
Score:  0.952
Data Source:  BioPlex,STRINGDB
GPATCH1
Tdark
Novelty:  0.93318176
p_int:  0.982581761
p_ni:  0.017418237
p_wrong:  2e-9
Score:  0.847
Data Source:  BioPlex,STRINGDB
ISY1
Tdark
Novelty:  1.68602768
p_int:  0.975796263
p_ni:  0.024203737
Score:  0.99
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fibrinogen measurement
8
14
14
12.9
99.8
7
5
2
1.2
98.2
low density lipoprotein cholesterol measurement
3
3
3
89.2
prothrombin time measurement
1
1
1
72.9
total cholesterol measurement
3
2
3
70.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fibrinogen measurement
14
12.9
99.8
2
1.2
98.2
low density lipoprotein cholesterol measurement
3
89.2
prothrombin time measurement
1
72.9
total cholesterol measurement
3
70.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pleiotropic regulator 1
VGNC:669
461557
Macaque
pleiotropic regulator 1
701044
Mouse
MGI:1858197
53317
Rat
RGD:621047
60376
Dog
pleiotropic regulator 1
VGNC:44710
612490
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pleiotropic regulator 1
Macaque
pleiotropic regulator 1
Mouse
Rat
Dog
pleiotropic regulator 1
Publication Statistics
PubMed Score 20.59
PubMed score by year
PubTator Score 7.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title