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Tbio
PLPPR3
Phospholipid phosphatase-related protein type 3

Protein Summary
Description
The proteins in the lipid phosphate phosphatase (LPP) family, including PRG2, are integral membrane proteins that modulate bioactive lipid phosphates including phosphatidate, lysophosphatidate, and sphingosine-1-phosphate in the context of cell migration, neurite retraction, and mitogenesis (Brauer et al., 2003 [PubMed 12730698]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359894
  • ENSP00000352962
  • ENSG00000129951
  • ENST00000520876
  • ENSP00000430297

Symbol
  • LPPR3
  • PHP2
  • PRG2
  • LPR3
  • PRG2
  • LPPR3
  • PRG-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.47   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.47   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
PLPPR1
Tdark
Family:  Enzyme
Novelty:  0.38109551
p_int:  0.999999416
p_ni:  5.8e-7
p_wrong:  4e-9
Score:  0.555
Data Source:  BioPlex,STRINGDB
ADGRG5
Tdark
Family:  GPCR
Novelty:  0.26575982
p_int:  0.99999528
p_ni:  0.000003297
p_wrong:  0.000001423
Data Source:  BioPlex
CHRND
Tclin
Family:  IC
Novelty:  0.0441685
p_int:  0.999936151
p_ni:  0.000004274
p_wrong:  0.000059575
Data Source:  BioPlex
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.999909391
p_ni:  0.000049315
p_wrong:  0.000041294
Data Source:  BioPlex
NKAIN1
Tdark
Family:  Enzyme
Novelty:  0.52190272
p_int:  0.905674356
p_ni:  0.000699632
p_wrong:  0.093626012
Data Source:  BioPlex
ZACN
Tchem
Family:  IC
Novelty:  0.21891621
p_int:  0.81872228
p_ni:  0.000042072
p_wrong:  0.181235648
Data Source:  BioPlex
LPCAT3
Tbio
Family:  Enzyme
Novelty:  0.00485213
Score:  0.916
Data Source:  STRINGDB
DGAT1
Tclin
Family:  Enzyme
Novelty:  0.00121009
Score:  0.915
Data Source:  STRINGDB
MBOAT2
Tbio
Family:  Enzyme
Novelty:  0.01820899
Score:  0.912
Data Source:  STRINGDB
MBOAT1
Tdark
Family:  Enzyme
Novelty:  0.05745641
Score:  0.909
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
GPCR ligand binding
Reactome
Lysosphingolipid and LPA receptors
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
GPCR ligand binding
Lysosphingolipid and LPA receptors
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
11
18
99.4
reticulocyte count
7
9
27
99.2
heel bone mineral density
3
4
6
94.5
serum gamma-glutamyl transferase measurement
2
2
3
93.1
hematocrit
2
2
3
93.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
18
99.4
reticulocyte count
27
99.2
heel bone mineral density
6
94.5
serum gamma-glutamyl transferase measurement
3
93.1
hematocrit
3
93.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2388640
216152
Rat
RGD:727823
314614
Dog
phospholipid phosphatase related 3
485096
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
phospholipid phosphatase related 3
Publication Statistics
PubMed Score 22.47
PubMed score by year
PubTator Score 1.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title