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Tdark
PLPPR2
Phospholipid phosphatase-related protein type 2

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251473
  • ENSP00000251473
  • ENSG00000105520
  • ENST00000591608
  • ENSP00000466898

Symbol
  • LPPR2
  • PRG4
  • PRG4
  • LPPR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.13   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.13   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
C9orf40
Tdark
Novelty:  2.72763898
p_int:  0.999932539
p_ni:  0.000067458
p_wrong:  3e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
DPP9
Tchem
Family:  Enzyme
Novelty:  0.00976924
p_int:  0.997569996
p_ni:  0.002430003
Data Source:  BioPlex
ISCA1
Tbio
Novelty:  0.01288069
p_int:  0.99714293
p_ni:  0.00285705
p_wrong:  2e-8
Data Source:  BioPlex
TTC5
Tbio
Novelty:  0.12127698
p_int:  0.992453771
p_ni:  0.007546229
Data Source:  BioPlex
DNAJC12
Tbio
Novelty:  0.05214775
p_int:  0.989049221
p_ni:  0.010950779
Data Source:  BioPlex
EPN1
Tbio
Novelty:  0.01788784
p_int:  0.989005207
p_ni:  0.010994729
p_wrong:  6.4e-8
Score:  0.198
Data Source:  BioPlex,STRINGDB
YTHDF1
Tbio
Novelty:  0.02063275
p_int:  0.983499656
p_ni:  0.016500344
Data Source:  BioPlex
METAP1
Tchem
Family:  Enzyme
Novelty:  0.01816253
p_int:  0.983109264
p_ni:  0.016890736
Score:  0.161
Data Source:  BioPlex,STRINGDB
SEC24D
Tbio
Novelty:  0.04795527
p_int:  0.971423947
p_ni:  0.028236365
p_wrong:  0.000339688
Score:  0.218
Data Source:  BioPlex,STRINGDB
METAP2
Tchem
Family:  Enzyme
Novelty:  0.00570955
p_int:  0.956756419
p_ni:  0.043243581
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
GPCR ligand binding
Reactome
Lysosphingolipid and LPA receptors
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
GPCR ligand binding
Lysosphingolipid and LPA receptors
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
2
2
2
80.2
diastolic blood pressure
1
1
1
78.6
Agents acting on the renin-angiotensin system use measurement
1
1
1
76.5
3
1
1
7.8
65.4
Calcium channel blocker use measurement
1
1
1
64.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
2
80.2
diastolic blood pressure
1
78.6
Agents acting on the renin-angiotensin system use measurement
1
76.5
1
7.8
65.4
Calcium channel blocker use measurement
1
64.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
phospholipid phosphatase related 2
714388
Mouse
MGI:2384575
235044
Rat
RGD:1597171
300443
Dog
phospholipid phosphatase related 2
484944
Horse
phospholipid phosphatase related 2
100057105
Species
Name
OMA
EggNOG
Inparanoid
Macaque
phospholipid phosphatase related 2
Mouse
Rat
Dog
phospholipid phosphatase related 2
Horse
phospholipid phosphatase related 2
Publication Statistics
PubMed Score 1.13
PubMed score by year
PubTator Score 0.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title