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Tdark
PLPPR1
Phospholipid phosphatase-related protein type 1

Protein Summary
Description
This gene encodes a member of the plasticity-related gene (PRG) family. Members of the PRG family mediate lipid phosphate phosphatase activity in neurons and are known to be involved in neuronal plasticity. The protein encoded by this gene does not perform its function through enzymatic phospholipid degradation. This gene is strongly expressed in brain. It shows dynamic expression regulation during brain development and neuronal excitation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374874
  • ENSP00000364008
  • ENSG00000148123
  • ENST00000395056
  • ENSP00000378496
  • ENST00000611695
  • ENSP00000478338
  • ENSG00000276539
  • ENST00000614834
  • ENSP00000477959

Symbol
  • LPPR1
  • PRG3
  • LPPR1
  • PRG-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.54   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 36   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.54   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (22)
PLPPR3
Tbio
Family:  Enzyme
Novelty:  0.03836833
p_int:  0.999999416
p_ni:  5.8e-7
p_wrong:  4e-9
Score:  0.555
Data Source:  BioPlex,STRINGDB
RAB23
Tbio
Family:  Enzyme
Novelty:  0.01686155
p_int:  0.999970952
p_ni:  0.000028987
p_wrong:  6.1e-8
Score:  0.527
Data Source:  BioPlex,STRINGDB
JAG2
Tbio
Novelty:  0.00176158
p_int:  0.998086974
p_ni:  0.00191302
p_wrong:  6e-9
Score:  0.214
Data Source:  BioPlex,STRINGDB
STX4
Tbio
Novelty:  0.00831588
p_int:  0.99555394
p_ni:  0.00444606
Score:  0.55
Data Source:  BioPlex,STRINGDB
STXBP3
Tbio
Novelty:  0.03346737
p_int:  0.985326131
p_ni:  0.014673869
Score:  0.792
Data Source:  BioPlex,STRINGDB
RAP1B
Tbio
Family:  Enzyme
Novelty:  0.00627538
p_int:  0.982282179
p_ni:  0.017717819
p_wrong:  2e-9
Score:  0.228
Data Source:  BioPlex,STRINGDB
LSG1
Tbio
Family:  Enzyme
Novelty:  0.05052924
p_int:  0.932824146
p_ni:  0.067175854
Score:  0.209
Data Source:  BioPlex,STRINGDB
RNF166
Tdark
Novelty:  0.71460884
p_int:  0.930832551
p_ni:  0.001244627
p_wrong:  0.067922822
Data Source:  BioPlex
NGEF
Tbio
Novelty:  0.04628547
Score:  0.617
Data Source:  STRINGDB
NEU2
Tbio
Family:  Enzyme
Novelty:  0.00460828
Score:  0.527
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
GPCR ligand binding
Reactome
Lysosphingolipid and LPA receptors
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
GPCR ligand binding
Lysosphingolipid and LPA receptors
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
1
1
85.2
C-reactive protein measurement
1
1
1
59
1
1
0
4.1
26.1
age at diagnosis
1
1
0
4.1
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
85.2
C-reactive protein measurement
1
59
0
4.1
26.1
age at diagnosis
0
4.1
26.1
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 3.54
PubMed score by year
PubTator Score 2.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title