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Tbio
PLPP4
Phospholipid phosphatase 4

Protein Summary
Description
Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398250
  • ENSP00000381302
  • ENSG00000203805

Symbol
  • DPPL2
  • PPAPDC1
  • PPAPDC1A
  • DPPL2
  • PPAPDC1
  • PPAPDC1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.75   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 80   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.75   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
RBFOX3
Tbio
Novelty:  0.00038317
p_int:  0.794072702
p_ni:  0.205338598
p_wrong:  0.000588701
Data Source:  BioPlex
DGAT1
Tclin
Family:  Enzyme
Novelty:  0.00121009
Score:  0.92
Data Source:  STRINGDB
LPCAT3
Tbio
Family:  Enzyme
Novelty:  0.00485213
Score:  0.916
Data Source:  STRINGDB
MOGAT1
Tbio
Family:  Enzyme
Novelty:  0.0503068
Score:  0.915
Data Source:  STRINGDB
DGAT2
Tchem
Family:  Enzyme
Novelty:  0.00488581
Score:  0.915
Data Source:  STRINGDB
MOGAT2
Tchem
Family:  Enzyme
Novelty:  0.06314447
Score:  0.915
Data Source:  STRINGDB
PLD2
Tchem
Family:  Enzyme
Novelty:  0.00331129
Score:  0.914
Data Source:  STRINGDB
PLD1
Tchem
Family:  Enzyme
Novelty:  0.00608142
Score:  0.914
Data Source:  STRINGDB
MBOAT1
Tdark
Family:  Enzyme
Novelty:  0.05745641
Score:  0.912
Data Source:  STRINGDB
CDS1
Tbio
Family:  Enzyme
Novelty:  0.08094799
Score:  0.912
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Fcgamma receptor (FCGR) dependent phagocytosis (R-HSA-2029480)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Role of phospholipids in phagocytosis
Name
Explore in Pharos
Explore in Source
Fcgamma receptor (FCGR) dependent phagocytosis
Immune System
Innate Immune System
Role of phospholipids in phagocytosis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Parkinson disease
1
1
1
52.9
phosphatidylcholine measurement
1
1
1
12.1
gut microbiome measurement
1
1
1
1.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Parkinson disease
1
52.9
phosphatidylcholine measurement
1
12.1
gut microbiome measurement
1
1.1
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipid phosphatase 4
VGNC:7253
741827
Macaque
phospholipid phosphatase 4
704483
Mouse
MGI:2685936
381925
Horse
phospholipid phosphatase 4
VGNC:51647
100065462
Pig
phospholipid phosphatase 4
100152806
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipid phosphatase 4
Macaque
phospholipid phosphatase 4
Mouse
Horse
phospholipid phosphatase 4
Pig
phospholipid phosphatase 4
Publication Statistics
PubMed Score 7.75
PubMed score by year
PubTator Score 2.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title