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Tbio
PLOD2
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

Protein Summary
Description
Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282903
  • ENSP00000282903
  • ENSG00000152952
  • ENST00000360060
  • ENSP00000353170
  • ENST00000461497
  • ENSP00000419354

Symbol
  • LH2
  • TLH
  • BRKS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
interacting protein
0.87
molecular function
0.76
virus perturbation
0.76
PubMedID
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 335.17   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 335.17   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (131)
COLQ
Tbio
Family:  Enzyme
Novelty:  0.01414634
p_int:  0.975072124
p_ni:  0.024927876
Score:  0.834
Data Source:  BioPlex,STRINGDB
PLOD1
Tbio
Family:  Enzyme
Novelty:  0.00905345
p_int:  0.77481272
p_ni:  0.22518728
Score:  0.972
Data Source:  BioPlex,Reactome,STRINGDB
COL5A2
Tbio
Novelty:  0.01352973
Score:  0.962
Data Source:  STRINGDB
COL1A1
Tbio
Novelty:  0.00063584
Score:  0.962
Data Source:  STRINGDB
COL1A2
Tbio
Novelty:  0.00048334
Score:  0.96
Data Source:  STRINGDB
COL5A1
Tbio
Novelty:  0.00506815
Score:  0.955
Data Source:  STRINGDB
COL4A1
Tbio
Novelty:  0.00358049
Score:  0.948
Data Source:  STRINGDB
COLGALT1
Tbio
Family:  Enzyme
Novelty:  0.14093826
Score:  0.947
Data Source:  STRINGDB
COL3A1
Tbio
Novelty:  0.00197327
Score:  0.944
Data Source:  STRINGDB
COL4A2
Tbio
Novelty:  0.00782053
Score:  0.943
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Collagen biosynthesis and modifying enzymes (R-HSA-1650814)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Collagen biosynthesis and modifying enzymes
Collagen formation
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
64.7
body height
1
1
1
58.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
64.7
body height
1
58.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
VGNC:9690
460754
Macaque
procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
715820
Mouse
MGI:1347007
26432
Rat
RGD:3353
300901
Dog
procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
VGNC:44702
485702
Species
Name
OMA
EggNOG
Inparanoid
Chimp
procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
Macaque
procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
Mouse
Rat
Dog
procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
Publication Statistics
PubMed Score 335.17
PubMed score by year
PubTator Score 224.05
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title