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Tbio
PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

Protein Summary
Description
Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (PubMed:8621606, PubMed:10686424, PubMed:15854030). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (Probable). Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. Two transcript ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000196061
  • ENSP00000196061
  • ENSG00000083444

Symbol
  • LLH
  • PLOD
  • LH
  • LH1
  • LLH
  • EDS6
  • PLOD
  • EDSKCL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.95
protein complex
0.88
molecular function
0.86
PubMedID
0.78
histone modification site profile
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.72   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.72   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (143)
COL4A6
Tbio
Novelty:  0.02524039
p_int:  0.999999981
p_ni:  1.6e-8
p_wrong:  4e-9
Score:  0.932
Data Source:  BioPlex,STRINGDB
COL4A5
Tbio
Novelty:  0.00283701
p_int:  0.999999977
p_ni:  1.5e-8
p_wrong:  8e-9
Score:  0.929
Data Source:  BioPlex,STRINGDB
COL4A1
Tbio
Novelty:  0.00358049
p_int:  0.999999975
p_ni:  2.2e-8
p_wrong:  3e-9
Score:  0.948
Data Source:  BioPlex,STRINGDB
COL5A1
Tbio
Novelty:  0.00506815
p_int:  0.99999971
p_ni:  2.9e-7
Score:  0.971
Data Source:  BioPlex,STRINGDB
COL2A1
Tbio
Novelty:  0.0011102
p_int:  0.999999588
p_ni:  4.12e-7
Score:  0.936
Data Source:  BioPlex,STRINGDB
MEX3D
Tdark
Novelty:  0.02245732
p_int:  0.999999479
p_ni:  5.18e-7
p_wrong:  4e-9
Score:  0.17
Data Source:  BioPlex,STRINGDB
COL4A2
Tbio
Novelty:  0.00782053
p_int:  0.999998756
p_ni:  0.000001244
Score:  0.937
Data Source:  BioPlex,STRINGDB
FOXA1
Tbio
Family:  TF
Novelty:  0.00235269
p_int:  0.99999362
p_ni:  1.4e-8
p_wrong:  0.000006366
Score:  0.199
Data Source:  BioPlex,STRINGDB
ODF2
Tbio
Novelty:  0.03203587
p_int:  0.999991298
p_ni:  8.33e-7
p_wrong:  0.000007869
Score:  0.173
Data Source:  BioPlex,STRINGDB
FAM122B
Tdark
Novelty:  1.90668674
p_int:  0.999987249
p_ni:  0.000012722
p_wrong:  2.8e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Collagen biosynthesis and modifying enzymes (R-HSA-1650814)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Collagen biosynthesis and modifying enzymes
Collagen formation
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
4
4
3
2.2
97.7
NT-proBNP measurement
2
3
3
95.2
platelet crit
2
2
2
95
BNP measurement
2
2
2
88.1
blood protein measurement
1
2
2
81.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
3
2.2
97.7
NT-proBNP measurement
3
95.2
platelet crit
2
95
BNP measurement
2
88.1
blood protein measurement
2
81.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
VGNC:10032
457956
Mouse
MGI:99907
18822
Rat
RGD:621382
116552
Dog
procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
VGNC:44701
487440
Horse
procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
VGNC:21585
100050902
Species
Name
OMA
EggNOG
Inparanoid
Chimp
procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
Mouse
Rat
Dog
procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
Horse
procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
Publication Statistics
PubMed Score 115.72
PubMed score by year
PubTator Score 140.06
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title