Tbio PLLP Plasmolipin

Protein Summary

Description

Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity).

Uniprot Accession IDs

• Q9Y342
• B2R9T6

Gene Name

• PLLP

Ensembl ID

• ENST00000219207
• ENSP00000219207
• ENSG00000102934

Symbol

• PMLP
• TM4SF11
• PMLP
• TM4SF11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.9
histone modification site profile	0.74
PubMedID	0.74
transcription factor binding site profile	0.66
transcription factor perturbation	0.61

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Plasmolipin

DTO Classes

Protein / Ion Channel / Plasmolipin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.56   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 90   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.56   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0