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Tchem
PLK4
Serine/threonine-protein kinase PLK4

Protein Summary
Description
Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270861
  • ENSP00000270861
  • ENSG00000142731
  • ENST00000513090
  • ENSP00000427554
  • ENST00000514379
  • ENSP00000423582

Symbol
  • SAK
  • STK18
  • SAK
  • STK18
  • MCCRP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
gene perturbation
0.89
histone modification site profile
0.89
transcription factor perturbation
0.88
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 590.87   (req: < 5)
Gene RIFs: 66   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 590.87   (req: >= 5)
Gene RIFs: 66   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 121
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (374)
PLOD1
Tbio
Family:  Enzyme
Novelty:  0.00905345
p_int:  0.967273689
p_ni:  0.032726311
Score:  0.199
Data Source:  BioPlex,STRINGDB
CEP152
Tbio
Novelty:  0.02129779
Score:  0.999
Data Source:  STRINGDB
CEP192
Tbio
Novelty:  0.05738998
Score:  0.997
Data Source:  STRINGDB
CEP135
Tbio
Novelty:  0.03507768
Score:  0.996
Data Source:  STRINGDB
CENPJ
Tbio
Novelty:  0.01337231
Score:  0.995
Data Source:  STRINGDB
STIL
Tbio
Novelty:  0.01053211
Score:  0.994
Data Source:  STRINGDB
CCP110
Tbio
Novelty:  0.02399511
Score:  0.993
Data Source:  STRINGDB
AURKA
Tchem
Family:  Kinase
Novelty:  0.0010868
Score:  0.988
Data Source:  STRINGDB
CDK1
Tchem
Family:  Kinase
Novelty:  0.00040776
Score:  0.987
Data Source:  STRINGDB
TUBGCP6
Tbio
Novelty:  0.05801955
Score:  0.987
Data Source:  STRINGDB
Pathways (57)
AURKA Activation by TPX2 (R-HSA-8854518)

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Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
30.2
reticulocyte measurement
1
1
1
25.8
IGF-1 measurement
1
1
1
22.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
30.2
reticulocyte measurement
1
25.8
IGF-1 measurement
1
22.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
polo like kinase 4
VGNC:7051
461480
Macaque
polo like kinase 4
710233
Mouse
MGI:101783
20873
Rat
RGD:1305390
310344
Dog
polo like kinase 4
VGNC:44698
476087
Species
Name
OMA
EggNOG
Inparanoid
Chimp
polo like kinase 4
Macaque
polo like kinase 4
Mouse
Rat
Dog
polo like kinase 4
Publication Statistics
PubMed Score 590.87
PubMed score by year
PubTator Score 141.77
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title