Protein Summary
Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE (By similarity). Members of the perilipin family, such as PLIN5, coat intra ...more
- ENST00000381848
- ENSP00000371272
- ENSG00000214456
- LSDP5
- OXPAT
- PAT-1
- MLDP
- LSDA5
- LSDP5
- OXPAT
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.78 | ||
transcription factor perturbation | 0.74 | ||
biological process | 0.67 | ||
virus perturbation | 0.64 | ||
tissue sample | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 106.86 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 129 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 106.86 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 129 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (33)
CFLAR
Novelty: 0.00108805
p_int: 0.999996885
p_ni: 0.000003115
Score: 0.538
Data Source: BioPlex,STRINGDB
SAPCD2
Novelty: 0.06798955
p_int: 0.999941801
p_ni: 0.000058188
p_wrong: 1e-8
Score: 0.52
Data Source: BioPlex,STRINGDB
ENC1
Novelty: 0.01942998
p_int: 0.998483427
p_ni: 0.000983319
p_wrong: 0.000533254
Score: 0.282
Data Source: BioPlex,STRINGDB
METAP2
Family: Enzyme
Novelty: 0.00570955
p_int: 0.990152942
p_ni: 0.009847058
Score: 0.211
Data Source: BioPlex,STRINGDB
INPPL1
Family: Enzyme
Novelty: 0.00634126
p_int: 0.976179596
p_ni: 0.023820404
Score: 0.196
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (1)
KEGG (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
KEGG | PPAR signaling pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
PPAR signaling pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (2)
Components (4)
Processes (13)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (25)
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mean corpuscular volume | 3 | 3 | 3 | 97.8 | |||||
hemoglobin measurement | 3 | 3 | 4 | 95.9 | |||||
mean reticulocyte volume | 1 | 2 | 2 | 95.1 | |||||
red blood cell distribution width | 4 | 2 | 4 | 93.7 | |||||
mean corpuscular hemoglobin concentration | 3 | 1 | 3 | 88.5 | |||||
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mean corpuscular volume | 3 | 97.8 | |||||
hemoglobin measurement | 4 | 95.9 | |||||
mean reticulocyte volume | 2 | 95.1 | |||||
red blood cell distribution width | 4 | 93.7 | |||||
mean corpuscular hemoglobin concentration | 3 | 88.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | perilipin 5 | VGNC:2285 | 738436 | |||||
Mouse | MGI:1914218 | 66968 | ||||||
Rat | RGD:1589602 | 501283 | ||||||
Dog | perilipin 5 | VGNC:44694 | 611877 | |||||
Cow | perilipin 5 | VGNC:33032 | 531199 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | perilipin 5 | |||||
Mouse | ||||||
Rat | ||||||
Dog | perilipin 5 | |||||
Cow | perilipin 5 | |||||
Publication Statistics
PubMed Score 106.86
PubMed score by year
PubTator Score 43.07
PubTator score by year
Related Publications
Text Mined References (14)
GeneRif Annotations (11)
Items per page:
0 of 0
PMID | Year | Title |
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