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Tbio
PLIN5
Perilipin-5

Protein Summary
Description
Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE (By similarity). Members of the perilipin family, such as PLIN5, coat intra ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381848
  • ENSP00000371272
  • ENSG00000214456

Symbol
  • LSDP5
  • OXPAT
  • PAT-1
  • MLDP
  • LSDA5
  • LSDP5
  • OXPAT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.78
transcription factor perturbation
0.74
biological process
0.67
virus perturbation
0.64
tissue sample
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.86   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.86   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
CFLAR
Tbio
Novelty:  0.00108805
p_int:  0.999996885
p_ni:  0.000003115
Score:  0.538
Data Source:  BioPlex,STRINGDB
SAPCD2
Tbio
Novelty:  0.06798955
p_int:  0.999941801
p_ni:  0.000058188
p_wrong:  1e-8
Score:  0.52
Data Source:  BioPlex,STRINGDB
ENC1
Tbio
Novelty:  0.01942998
p_int:  0.998483427
p_ni:  0.000983319
p_wrong:  0.000533254
Score:  0.282
Data Source:  BioPlex,STRINGDB
METAP2
Tchem
Family:  Enzyme
Novelty:  0.00570955
p_int:  0.990152942
p_ni:  0.009847058
Score:  0.211
Data Source:  BioPlex,STRINGDB
INPPL1
Tchem
Family:  Enzyme
Novelty:  0.00634126
p_int:  0.976179596
p_ni:  0.023820404
Score:  0.196
Data Source:  BioPlex,STRINGDB
PNPLA2
Tchem
Family:  Enzyme
Novelty:  0.00149181
Score:  0.924
Data Source:  STRINGDB
ABHD5
Tbio
Family:  Enzyme
Novelty:  0.00806614
Score:  0.857
Data Source:  STRINGDB
LIPE
Tchem
Family:  Enzyme
Novelty:  0.00169872
Score:  0.734
Data Source:  STRINGDB
CIDEA
Tbio
Novelty:  0.00901749
Score:  0.728
Data Source:  STRINGDB
CIDEC
Tbio
Novelty:  0.01081754
Score:  0.689
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
3
3
3
97.8
hemoglobin measurement
3
3
4
95.9
mean reticulocyte volume
1
2
2
95.1
red blood cell distribution width
4
2
4
93.7
mean corpuscular hemoglobin concentration
3
1
3
88.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
3
97.8
hemoglobin measurement
4
95.9
mean reticulocyte volume
2
95.1
red blood cell distribution width
4
93.7
mean corpuscular hemoglobin concentration
3
88.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
perilipin 5
VGNC:2285
738436
Mouse
MGI:1914218
66968
Rat
RGD:1589602
501283
Dog
perilipin 5
VGNC:44694
611877
Cow
perilipin 5
VGNC:33032
531199
Species
Name
OMA
EggNOG
Inparanoid
Chimp
perilipin 5
Mouse
Rat
Dog
perilipin 5
Cow
perilipin 5
Publication Statistics
PubMed Score 106.86
PubMed score by year
PubTator Score 43.07
PubTator score by year
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Related Publications
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PMID
Year
Title