Tbio PLIN5 Perilipin-5

Protein Summary

Description

Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE (By similarity). Members of the perilipin family, such as PLIN5, coat intracellular lipid storage droplets and protect them from lipolytic degradation (Dalen et al., 2007 [PubMed 17234449]).[supplied by OMIM, Feb 2010]

Uniprot Accession IDs

• Q00G26
• A2RRC1
• Q6ZS68

Gene Name

• PLIN5

Ensembl ID

• ENST00000381848
• ENSP00000371272
• ENSG00000214456

Symbol

• LSDP5
• OXPAT
• PAT-1
• MLDP
• LSDA5
• LSDP5
• OXPAT

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.78
transcription factor perturbation	0.74
biological process	0.67
virus perturbation	0.64
tissue sample	0.63

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Perilipin-5

DTO Classes

Protein / Transporter / Perilipin-5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.86   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 129   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.86   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (33)

Explore Interacting Targets

1 – 10 of 33

• See Interactions on String-DB

CFLAR

Tbio

Novelty:  0.00108805

p_int:  0.999996885

p_ni:  0.000003115

Score:  0.538

Data Source:  BioPlex,STRINGDB

SAPCD2

Tbio

Novelty:  0.06798955

p_int:  0.999941801

p_ni:  0.000058188

p_wrong:  1e-8

Score:  0.52

Data Source:  BioPlex,STRINGDB

ENC1

Tbio

Novelty:  0.01942998

p_int:  0.998483427

p_ni:  0.000983319

p_wrong:  0.000533254

Score:  0.282

Data Source:  BioPlex,STRINGDB

METAP2

Tchem

Family:  Enzyme

Novelty:  0.00570955

p_int:  0.990152942

p_ni:  0.009847058

Score:  0.211

Data Source:  BioPlex,STRINGDB

INPPL1

Tchem

Family:  Enzyme

Novelty:  0.00634126

p_int:  0.976179596

p_ni:  0.023820404

Score:  0.196

Data Source:  BioPlex,STRINGDB

PNPLA2

Tchem

Family:  Enzyme

Novelty:  0.00149181

Score:  0.924

Data Source:  STRINGDB

ABHD5

Tbio

Family:  Enzyme

Novelty:  0.00806614

Score:  0.857

Data Source:  STRINGDB

LIPE

Tchem

Family:  Enzyme

Novelty:  0.00169872

Score:  0.734

Data Source:  STRINGDB

CIDEA

Tbio

Novelty:  0.00901749

Score:  0.728

Data Source:  STRINGDB

CIDEC

Tbio

Novelty:  0.01081754

Score:  0.689

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

KEGG (1)

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Data Source	Name	Explore in Pharos	Explore in Source
KEGG	PPAR signaling pathway	76 targets	path:hsa03320

Name	Explore in Pharos	Explore in Source
PPAR signaling pathway	76 targets	path:hsa03320

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (19)

Functions (2)

Components (4)

Processes (13)

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10

1 – 2 of 2

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Electronic Annotation (IEA)	Ensembl
lipase binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations (null)

No disease associations found

GWAS Traits (25)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 25

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular volume	EFO_0004526	3	3	3		97.8
hemoglobin measurement	EFO_0004509	3	3	4		95.9
mean reticulocyte volume	EFO_0010701	1	2	2		95.1
red blood cell distribution width	EFO_0005192	4	2	4		93.7
mean corpuscular hemoglobin concentration	EFO_0004528	3	1	3		88.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 25

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular volume	EFO_0004526	3		97.8
hemoglobin measurement	EFO_0004509	4		95.9
mean reticulocyte volume	EFO_0010701	2		95.1
red blood cell distribution width	EFO_0005192	4		93.7
mean corpuscular hemoglobin concentration	EFO_0004528	3		88.5

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UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Cytoplasm
Lipid droplet
Mitochondrion
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted hip circumference
BMI-adjusted waist-hip ratio
creatinine measurement
erythrocyte count
glomerular filtration rate
hematocrit
hemoglobin measurement
intelligence
low density lipoprotein cholesterol measurement
mean corpuscular hemoglobin

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
homeostasis/metabolism phenotype
liver/biliary system phenotype
muscle phenotype

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	perilipin 5	VGNC:2285	738436
Mouse	perilipin 5	MGI:1914218	66968
Rat	perilipin 5	RGD:1589602	501283
Dog	perilipin 5	VGNC:44694	611877
Cow	perilipin 5	VGNC:33032	531199

Species	Name	OMA	EggNOG	Inparanoid
Chimp	perilipin 5
Mouse	perilipin 5
Rat	perilipin 5
Dog	perilipin 5
Cow	perilipin 5

Publication Statistics

PubMed Score 106.86

PubMed score by year

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PubTator Score 43.07

PubTator score by year

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Related Publications

Text Mined References (14)

GeneRif Annotations (11)

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PMID	Year	Title