Protein Summary
Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo. The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin in ...more
- ENST00000308192
- ENSP00000308938
- ENSG00000122194
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
gene perturbation | 0.97 | ||
biological process | 0.82 | ||
disease perturbation | 0.79 | ||
cellular component | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19481.08 (req: < 5)
Gene RIFs: 205 (req: <= 3)
Antibodies: 1218 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19481.08 (req: >= 5)
Gene RIFs: 205 (req: > 3)
Antibodies: 1218 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 27
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 324
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 8
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (8)
Active Ligands (324)
Protein-Protein Interactions (310)
SLC6A1
Family: Transporter
Novelty: 0.00165116
p_int: 0.999982761
p_ni: 0.000009006
p_wrong: 0.000008234
Data Source: BioPlex
FAM32A
Novelty: 1.12040581
p_int: 0.855042667
p_ni: 0.144957332
p_wrong: 1e-9
Data Source: BioPlex
Nearest Tclin Targets
Pathways (31)
Reactome (13)
KEGG (4)
PathwayCommons (7)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of Matrix Metalloproteinases | ||||
Reactome | Degradation of the extracellular matrix | ||||
Reactome | Dissolution of Fibrin Clot | ||||
Reactome | Extracellular matrix organization | ||||
Reactome | Hemostasis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of Matrix Metalloproteinases | ||||
Degradation of the extracellular matrix | ||||
Dissolution of Fibrin Clot | ||||
Extracellular matrix organization | ||||
Hemostasis | ||||
Viral Interactions (0)
Gene Ontology Terms (37)
Functions (11)
Components (10)
Processes (16)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | AgBase | |||
Disease Associations (null)
GWAS Traits (17)
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
lipoprotein A measurement | 3 | 19 | 3 | 9.1 | 99.9 | ||||
apolipoprotein A 1 measurement | 1 | 6 | 0 | 11.7 | 99.2 | ||||
4 | 4 | 3 | 1.2 | 97.6 | |||||
triglyceride measurement | 3 | 4 | 4 | 94.2 | |||||
plasma plasminogen measurement | 1 | 2 | 2 | 80.8 | |||||
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
lipoprotein A measurement | 3 | 9.1 | 99.9 | ||||
apolipoprotein A 1 measurement | 0 | 11.7 | 99.2 | ||||
3 | 1.2 | 97.6 | |||||
triglyceride measurement | 4 | 94.2 | |||||
plasma plasminogen measurement | 2 | 80.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | plasminogen | VGNC:11165 | 463117 | |||||
Macaque | plasminogen | 703891 | ||||||
Mouse | MGI:97620 | 18815 | ||||||
Rat | RGD:619893 | 85253 | ||||||
Dog | plasminogen | 403602 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | plasminogen | |||||
Macaque | plasminogen | |||||
Mouse | ||||||
Rat | ||||||
Dog | plasminogen | |||||
Publication Statistics
PubMed Score 19481.08
PubMed score by year
PubTator Score 3644.94
PubTator score by year
Related Publications
Text Mined References (373)
GeneRif Annotations (205)
Items per page:
0 of 0
PMID | Year | Title |
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