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Tdark
PLEKHO2
Pleckstrin homology domain-containing family O member 2

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323544
  • ENSP00000326706
  • ENSG00000241839
  • ENST00000616065
  • ENSP00000483505

Symbol
  • PLEKHQ1
  • PP1628
  • pp9099
  • PLEKHQ1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
cell type or tissue
0.85
transcription factor binding site profile
0.74
transcription factor
0.71
cellular component
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
CAPZA2
Tbio
Novelty:  0.14014918
p_int:  1
Score:  0.291
Data Source:  BioPlex,STRINGDB
TACC3
Tbio
Novelty:  0.00708723
p_int:  0.999999831
p_ni:  1.69e-7
Data Source:  BioPlex
MAP3K6
Tchem
Family:  Kinase
Novelty:  0.03743265
p_int:  0.999999797
p_ni:  2.02e-7
p_wrong:  1e-9
Score:  0.24
Data Source:  BioPlex,STRINGDB
UBR2
Tbio
Family:  Enzyme
Novelty:  0.03126228
p_int:  0.999998241
p_ni:  0.000001759
Data Source:  BioPlex
CENPJ
Tbio
Novelty:  0.01337231
p_int:  0.999998013
p_ni:  0.000001986
p_wrong:  1e-9
Score:  0.28
Data Source:  BioPlex,STRINGDB
FAM184A
Tdark
Novelty:  2.0967899
p_int:  0.999996073
p_ni:  0.000003911
p_wrong:  1.6e-8
Score:  0.332
Data Source:  BioPlex,STRINGDB
FLAD1
Tbio
Family:  Enzyme
Novelty:  0.02230368
p_int:  0.999854038
p_ni:  0.000145962
Score:  0.243
Data Source:  BioPlex,STRINGDB
CAPZB
Tbio
Novelty:  0.03509224
p_int:  0.999064342
p_ni:  0.000935658
Score:  0.836
Data Source:  BioPlex,STRINGDB
CAPZA1
Tbio
Novelty:  0.03448517
p_int:  0.998651971
p_ni:  0.001348029
Score:  0.847
Data Source:  BioPlex,STRINGDB
FAAP100
Tdark
Novelty:  0.1698504
p_int:  0.982595003
p_ni:  0.012197045
p_wrong:  0.005207952
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
5
5
3.4
97.6
mean platelet volume
2
2
2
86.7
platelet crit
1
2
2
74.8
electrocardiography
1
1
1
21.5
pulse pressure measurement
1
1
1
12.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
3.4
97.6
mean platelet volume
2
86.7
platelet crit
2
74.8
electrocardiography
1
21.5
pulse pressure measurement
1
12.6
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pleckstrin homology domain containing O2
VGNC:13417
467705
Macaque
pleckstrin homology domain containing O2
712677
Mouse
MGI:2143132
102595
Rat
RGD:1305718
315764
Dog
pleckstrin homology domain containing O2
487597
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pleckstrin homology domain containing O2
Macaque
pleckstrin homology domain containing O2
Mouse
Rat
Dog
pleckstrin homology domain containing O2
Publication Statistics
PubMed Score 3.00
PubMed score by year
PubTator Score 0.05
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title