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Tbio
PLEKHO1
Pleckstrin homology domain-containing family O member 1

Protein Summary
Description
Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369124
  • ENSP00000358120
  • ENSG00000023902

Symbol
  • CKIP1
  • OC120
  • JBP
  • CKIP1
  • OC120
  • CKIP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
gene perturbation
0.74
PubMedID
0.68
cell type or tissue
0.62
small molecule perturbation
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.56   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 171   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.56   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (78)
CAPZA2
Tbio
Novelty:  0.14014918
p_int:  1
Score:  0.482
Data Source:  BioPlex,STRINGDB
SEC24D
Tbio
Novelty:  0.04795527
p_int:  0.999561982
p_ni:  0.000437993
p_wrong:  2.5e-8
Score:  0.181
Data Source:  BioPlex,STRINGDB
CENPV
Tbio
Novelty:  0.00175994
p_int:  0.997331232
p_ni:  0.001353171
p_wrong:  0.001315597
Data Source:  BioPlex
CAPZA1
Tbio
Novelty:  0.03448517
p_int:  0.990114244
p_ni:  0.009885756
Score:  0.579
Data Source:  BioPlex,STRINGDB
CAPZB
Tbio
Novelty:  0.03509224
p_int:  0.989395162
p_ni:  0.010604838
Score:  0.84
Data Source:  BioPlex,STRINGDB
RPL26L1
Tdark
Novelty:  0.75408617
p_int:  0.971776998
p_ni:  0.028223002
Data Source:  BioPlex
PDCD11
Tbio
Novelty:  0.02209612
p_int:  0.96850605
p_ni:  0.03149395
Data Source:  BioPlex
UBA6
Tchem
Novelty:  0.05213412
p_int:  0.964660167
p_ni:  0.035339362
p_wrong:  4.71e-7
Data Source:  BioPlex
FLNC
Tbio
Novelty:  0.00463205
p_int:  0.954085626
p_ni:  0.045914374
Data Source:  BioPlex
SPTY2D1
Tdark
Novelty:  0.75211025
p_int:  0.945898989
p_ni:  0.054101005
p_wrong:  6e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
3
2
1
89.6
HbA1c measurement
1
1
1
58.4
glomerular filtration rate
2
2
2
57.8
apolipoprotein A 1 measurement
1
2
2
55.1
high density lipoprotein cholesterol measurement
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
1
89.6
HbA1c measurement
1
58.4
glomerular filtration rate
2
57.8
apolipoprotein A 1 measurement
2
55.1
high density lipoprotein cholesterol measurement
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pleckstrin homology domain containing O1
VGNC:6946
457268
Macaque
pleckstrin homology domain containing O1
706145
Mouse
MGI:1914470
67220
Rat
RGD:1311487
310674
Dog
pleckstrin homology domain containing O1
VGNC:44687
607927
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pleckstrin homology domain containing O1
Macaque
pleckstrin homology domain containing O1
Mouse
Rat
Dog
pleckstrin homology domain containing O1
Publication Statistics
PubMed Score 82.56
PubMed score by year
PubTator Score 28.33
PubTator score by year
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Related Publications
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PMID
Year
Title