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Tdark
PLEKHH3
Pleckstrin homology domain-containing family H member 3

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000591022
  • ENSP00000468678
  • ENSG00000068137
  • ENST00000591196
  • ENSP00000467824
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
transcription factor binding site profile
0.82
transcription factor
0.7
cell type or tissue
0.68
histone modification site profile
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.56   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 30   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.56   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (26)
MAPK4
Tbio
Family:  Kinase
Novelty:  0.0223868
p_int:  0.97500397
p_ni:  0.02499603
Data Source:  BioPlex
TGFBR2
Tchem
Family:  Kinase
Novelty:  0.00085381
p_int:  0.969212294
p_ni:  0.030787706
Score:  0.199
Data Source:  BioPlex,STRINGDB
MANSC1
Tdark
Novelty:  0.91681036
p_int:  0.964466451
p_ni:  0.035533549
Data Source:  BioPlex
PTGER3
Tclin
Family:  GPCR
Novelty:  0.0012681
p_int:  0.944927157
p_ni:  0.055072843
Score:  0.174
Data Source:  BioPlex,STRINGDB
IL4R
Tclin
Novelty:  0.00359183
p_int:  0.936232393
p_ni:  0.063767607
Score:  0.201
Data Source:  BioPlex,STRINGDB
HAVCR2
Tbio
Novelty:  0.00155885
p_int:  0.932534383
p_ni:  0.067465617
Data Source:  BioPlex
SKAP1
Tbio
Family:  Enzyme
Novelty:  0.03753848
p_int:  0.900580392
p_ni:  0.099419608
Data Source:  BioPlex
TMED7
Tdark
Novelty:  0.31193294
p_int:  0.888229893
p_ni:  0.111770107
Data Source:  BioPlex
TACR3
Tchem
Family:  GPCR
Novelty:  0.00351352
p_int:  0.833756721
p_ni:  0.166243279
Data Source:  BioPlex
EFNB2
Tbio
Novelty:  0.00255095
p_int:  0.800094703
p_ni:  0.199905297
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
2
6
6
81.8
BMI-adjusted waist-hip ratio
2
6
6
79.8
sex hormone-binding globulin measurement
2
1
2
70.8
4
3
1
1.1
68.8
waist circumference
1
2
2
43.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
6
81.8
BMI-adjusted waist-hip ratio
6
79.8
sex hormone-binding globulin measurement
2
70.8
1
1.1
68.8
waist circumference
2
43.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
pleckstrin homology, MyTH4 and FERM domain containing H3
711013
Mouse
MGI:2384950
217198
Rat
RGD:1304854
360634
Horse
pleckstrin homology, MyTH4 and FERM domain containing H3
VGNC:21574
100065971
Cow
pleckstrin homology, MyTH4 and FERM domain containing H3
VGNC:33022
541100
Species
Name
OMA
EggNOG
Inparanoid
Macaque
pleckstrin homology, MyTH4 and FERM domain containing H3
Mouse
Rat
Horse
pleckstrin homology, MyTH4 and FERM domain containing H3
Cow
pleckstrin homology, MyTH4 and FERM domain containing H3
Publication Statistics
PubMed Score 0.56
PubMed score by year
PubTator Score 0.34
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title