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Tbio
PLEKHG6
Pleckstrin homology domain-containing family G member 6

Protein Summary
Description
Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000011684
  • ENSP00000011684
  • ENSG00000008323
  • ENST00000304581
  • ENSP00000304640
  • ENST00000396988
  • ENSP00000380185
  • ENST00000449001
  • ENSP00000393194

Symbol
  • MyoGEF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.68
protein domain
0.58
small molecule perturbation
0.52
cellular component
0.49
PubMedID
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.68   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.68   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
PCDHGA5
Tdark
Novelty:  2.13631603
p_int:  0.999999835
p_ni:  1.65e-7
Data Source:  BioPlex
BPIFA2
Tbio
Novelty:  0.01533858
p_int:  0.999976695
p_ni:  0.000023225
p_wrong:  7.9e-8
Score:  0.169
Data Source:  BioPlex,STRINGDB
CST1
Tbio
Novelty:  0.02399609
p_int:  0.999721734
p_ni:  0.000128559
p_wrong:  0.000149707
Data Source:  BioPlex
CARNMT1
Tbio
Family:  Enzyme
Novelty:  0.28121779
p_int:  0.983186803
p_ni:  0.016813197
Data Source:  BioPlex
CST5
Tbio
Novelty:  0.04273227
p_int:  0.983073696
p_ni:  0.000059224
p_wrong:  0.016867079
Score:  0.163
Data Source:  BioPlex,STRINGDB
PIGR
Tbio
Novelty:  0.0025812
p_int:  0.981785191
p_ni:  0.018209079
p_wrong:  0.00000573
Data Source:  BioPlex
JCHAIN
Tbio
Novelty:  0.00172454
p_int:  0.98128714
p_ni:  0.018693877
p_wrong:  0.000018983
Data Source:  BioPlex
ZG16B
Tbio
Novelty:  0.08792924
p_int:  0.978161185
p_ni:  0.021838811
p_wrong:  4e-9
Data Source:  BioPlex
GSN
Tbio
Novelty:  0.00060852
p_int:  0.938806474
p_ni:  0.061193526
Score:  0.541
Data Source:  BioPlex,STRINGDB
ACTB
Tbio
Novelty:  0.00006048
p_int:  0.931313281
p_ni:  0.068686719
Score:  0.173
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (35)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
multiple sclerosis
5
4
0
1.1
98.8
primary biliary cirrhosis
3
2
1
1.3
91.9
lymphocyte count
5
5
8
90.8
platelet crit
2
6
6
87.3
monocyte count
3
3
4
87.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
multiple sclerosis
0
1.1
98.8
primary biliary cirrhosis
1
1.3
91.9
lymphocyte count
8
90.8
platelet crit
6
87.3
monocyte count
4
87.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pleckstrin homology and RhoGEF domain containing G6
VGNC:5537
466933
Macaque
pleckstrin homology and RhoGEF domain containing G6
722030
Mouse
MGI:2682298
213522
Rat
RGD:2318544
100362241
Dog
pleckstrin homology and RhoGEF domain containing G6
VGNC:44681
477717
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pleckstrin homology and RhoGEF domain containing G6
Macaque
pleckstrin homology and RhoGEF domain containing G6
Mouse
Rat
Dog
pleckstrin homology and RhoGEF domain containing G6
Publication Statistics
PubMed Score 7.68
PubMed score by year
PubTator Score 6.33
PubTator score by year
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Related Publications
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PMID
Year
Title