PLEKHG5
Pleckstrin homology domain-containing family G member 5
Protein Summary
Guanine nucleotide exchange factor that activates RHOA and maybe the NF-kappa-B signaling pathway. Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis. This gene encodes a protein that activates the nuclear factor kappa B (NFKB1) signaling pathway. Mutations in this gene are associated with autosomal recessive distal spinal muscular atrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
- ENST00000340850
- ENSP00000344570
- ENSG00000171680
- ENST00000377725
- ENSP00000366954
- ENST00000377728
- ENSP00000366957
- ENST00000377732
- ENSP00000366961
- ENST00000377748
- ENSP00000366977
- ENST00000400913
- ENSP00000383704
- ENST00000400915
- ENSP00000383706
- ENST00000535355
- ENSP00000441445
- ENST00000537245
- ENSP00000439625
- KIAA0720
- Syx
- Tech
- DSMA4
- CMTRIC
- GEF720
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue sample | 0.66 | ||
transcription factor | 0.64 | ||
disease perturbation | 0.62 | ||
tissue | 0.6 | ||
disease | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 52.32 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 123 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 52.32 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 123 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0