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Tbio
PLEKHG5
Pleckstrin homology domain-containing family G member 5

Protein Summary
Description
Guanine nucleotide exchange factor that activates RHOA and maybe the NF-kappa-B signaling pathway. Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis. This gene encodes a protein that activates the nuclear factor kappa B (NFKB1) signaling pathway. Mutations in this gene are associated with autosomal recessive distal spinal muscular atrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340850
  • ENSP00000344570
  • ENSG00000171680
  • ENST00000377725
  • ENSP00000366954
  • ENST00000377728
  • ENSP00000366957
  • ENST00000377732
  • ENSP00000366961
  • ENST00000377748
  • ENSP00000366977
  • ENST00000400913
  • ENSP00000383704
  • ENST00000400915
  • ENSP00000383706
  • ENST00000535355
  • ENSP00000441445
  • ENST00000537245
  • ENSP00000439625

Symbol
  • KIAA0720
  • Syx
  • Tech
  • DSMA4
  • CMTRIC
  • GEF720
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.66
transcription factor
0.64
disease perturbation
0.62
tissue
0.6
disease
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.32   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.32   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0