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Tbio
PLEKHG5
Pleckstrin homology domain-containing family G member 5

Protein Summary
Description
Guanine nucleotide exchange factor that activates RHOA and maybe the NF-kappa-B signaling pathway. Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis. This gene encodes a protein that activates the nuclear factor kappa B (NFKB1) signaling pathway. Mutations in this gene are associated with autosomal recessive distal spinal muscular atrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340850
  • ENSP00000344570
  • ENSG00000171680
  • ENST00000377725
  • ENSP00000366954
  • ENST00000377728
  • ENSP00000366957
  • ENST00000377732
  • ENSP00000366961
  • ENST00000377748
  • ENSP00000366977
  • ENST00000400913
  • ENSP00000383704
  • ENST00000400915
  • ENSP00000383706
  • ENST00000535355
  • ENSP00000441445
  • ENST00000537245
  • ENSP00000439625

Symbol
  • KIAA0720
  • Syx
  • Tech
  • DSMA4
  • CMTRIC
  • GEF720
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.66
transcription factor
0.64
disease perturbation
0.62
tissue
0.6
disease
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.32   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.32   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
BTRC
Tbio
Novelty:  0.00293475
p_int:  0.999862837
p_ni:  0.000137163
Data Source:  BioPlex
FBXW11
Tbio
Novelty:  0.0715377
p_int:  0.998766999
p_ni:  0.001233001
Data Source:  BioPlex
YWHAE
Tbio
Novelty:  0.00431876
p_int:  0.993595594
p_ni:  0.006404406
Score:  0.272
Data Source:  BioPlex,STRINGDB
YWHAZ
Tchem
Novelty:  0.00210582
p_int:  0.993410715
p_ni:  0.006589285
Score:  0.227
Data Source:  BioPlex,STRINGDB
YWHAG
Tchem
Novelty:  0.00845572
p_int:  0.962208906
p_ni:  0.037791094
Score:  0.235
Data Source:  BioPlex,STRINGDB
PDP1
Tbio
Family:  Enzyme
Novelty:  0.00442352
p_int:  0.961231197
p_ni:  0.038768803
Score:  0.163
Data Source:  BioPlex,STRINGDB
GNB4
Tbio
Novelty:  0.08250797
p_int:  0.935924218
p_ni:  0.058259567
p_wrong:  0.005816215
Score:  0.297
Data Source:  BioPlex,STRINGDB
YWHAH
Tbio
Novelty:  0.01000071
p_int:  0.87393733
p_ni:  0.12606267
Score:  0.25
Data Source:  BioPlex,STRINGDB
YWHAQ
Tbio
Novelty:  0.00234496
p_int:  0.775798212
p_ni:  0.224201788
Score:  0.276
Data Source:  BioPlex,STRINGDB
USP7
Tchem
Family:  Enzyme
Novelty:  0.00412878
p_int:  0.774167904
p_ni:  0.225832096
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Cell death signalling via NRAGE, NRIF and NADE (R-HSA-204998)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Death Receptor Signalling
Reactome
G alpha (12/13) signalling events
Reactome
GPCR downstream signalling
Reactome
NRAGE signals death through JNK
Name
Explore in Pharos
Explore in Source
Cell death signalling via NRAGE, NRIF and NADE
Death Receptor Signalling
G alpha (12/13) signalling events
GPCR downstream signalling
NRAGE signals death through JNK
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
multiple sclerosis
2
2
0
1.1
90.3
heel bone mineral density
1
1
1
78.8
FEV/FEC ratio
1
1
1
78.2
type 2 diabetes mellitus
2
2
2
74.2
comparative body size at age 10, self-reported
1
1
1
61.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
multiple sclerosis
0
1.1
90.3
heel bone mineral density
1
78.8
FEV/FEC ratio
1
78.2
type 2 diabetes mellitus
2
74.2
comparative body size at age 10, self-reported
1
61.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pleckstrin homology and RhoGEF domain containing G5
VGNC:6945
457897
Macaque
pleckstrin homology and RhoGEF domain containing G5
703518
Mouse
MGI:2652860
269608
Rat
RGD:1303132
310999
Dog
pleckstrin homology and RhoGEF domain containing G5
VGNC:44680
479590
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pleckstrin homology and RhoGEF domain containing G5
Macaque
pleckstrin homology and RhoGEF domain containing G5
Mouse
Rat
Dog
pleckstrin homology and RhoGEF domain containing G5
Publication Statistics
PubMed Score 52.32
PubMed score by year
PubTator Score 72.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title