Protein Summary
Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi. The protein encoded by this gene can function as a guanine nucleotide exchange factor (GEF) and may play a role in intracellular signaling and cytoskeleton dynamics at the Golgi apparatus. Polymorphisms in the region of this gene have been found to be associated with spinocerebellar ataxia in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
- ENST00000360461
- ENSP00000353646
- ENSG00000196155
- ENST00000379344
- ENSP00000368649
- ENST00000393966
- ENSP00000462601
- ENST00000427155
- ENSP00000401118
- ENST00000450733
- ENSP00000398030
- ENST00000563969
- ENSP00000457086
- PRTPHN1
- SCA4
- PRTPHN1
- ARHGEF44
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor | 0.79 | ||
tissue sample | 0.64 | ||
transcription factor binding site profile | 0.6 | ||
protein domain | 0.58 | ||
tissue | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 94.83 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 85 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 94.83 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 85 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (59)
UBE2O
Novelty: 0.07084123
p_int: 0.999690457
p_ni: 0.000309542
Score: 0.159
Data Source: BioPlex,STRINGDB
DOCK5
Novelty: 0.03153692
p_int: 0.928924619
p_ni: 0.071075381
Score: 0.226
Data Source: BioPlex,STRINGDB
PTGER3
Family: GPCR
Novelty: 0.0012681
p_int: 0.884470801
p_ni: 0.115529198
p_wrong: 2e-9
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (3)
Functions (1)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular volume | 1 | 4 | 4 | 96.2 | |||||
mean reticulocyte volume | 1 | 4 | 4 | 94.2 | |||||
heel bone mineral density | 3 | 3 | 6 | 93.1 | |||||
BMI-adjusted waist-hip ratio | 5 | 3 | 9 | 77.1 | |||||
BMI-adjusted waist circumference | 5 | 5 | 8 | 65.7 | |||||
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular volume | 4 | 96.2 | |||||
mean reticulocyte volume | 4 | 94.2 | |||||
heel bone mineral density | 6 | 93.1 | |||||
BMI-adjusted waist-hip ratio | 9 | 77.1 | |||||
BMI-adjusted waist circumference | 8 | 65.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | pleckstrin homology and RhoGEF domain containing G4 | VGNC:5865 | 454164 | |||||
Macaque | pleckstrin homology and RhoGEF domain containing G4 | 699160 | ||||||
Mouse | MGI:2142544 | 102075 | ||||||
Rat | RGD:1310790 | 307796 | ||||||
Dog | pleckstrin homology and RhoGEF domain containing G4 | VGNC:44679 | 489759 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | pleckstrin homology and RhoGEF domain containing G4 | |||||
Macaque | pleckstrin homology and RhoGEF domain containing G4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | pleckstrin homology and RhoGEF domain containing G4 | |||||
Publication Statistics
PubMed Score 94.83
PubMed score by year
PubTator Score 36.89
PubTator score by year
Related Publications
Text Mined References (22)
GeneRif Annotations (14)
Items per page:
0 of 0
PMID | Year | Title |
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