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Tbio
PLEKHB1
Pleckstrin homology domain-containing family B member 1

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000227214
  • ENSP00000227214
  • ENSG00000021300
  • ENST00000354190
  • ENSP00000346127
  • ENST00000398492
  • ENSP00000381505
  • ENST00000398494
  • ENSP00000381507
  • ENST00000535129
  • ENSP00000442616

Symbol
  • EVT1
  • KPL1
  • PHR1
  • PHRET1
  • KPL1
  • PHR1
  • PHRET1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
transcription factor
0.78
small molecule perturbation
0.74
hub protein
0.71
tissue
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.17   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 47   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.17   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 47   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
RAP1GDS1
Tbio
Family:  Enzyme
Novelty:  0.06140479
p_int:  0.999998081
p_ni:  8.93e-7
p_wrong:  0.000001026
Score:  0.288
Data Source:  BioPlex,STRINGDB
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.999935844
p_ni:  0.000006621
p_wrong:  0.000057535
Data Source:  BioPlex
RBFOX2
Tbio
Novelty:  0.00856339
p_int:  0.9973014
p_ni:  0.000004253
p_wrong:  0.002694348
Score:  0.211
Data Source:  BioPlex,STRINGDB
MANSC1
Tdark
Novelty:  0.91681036
p_int:  0.994130969
p_ni:  0.000003853
p_wrong:  0.005865178
Data Source:  BioPlex
MYCBP2
Tbio
Family:  Enzyme
Novelty:  0.00413684
Score:  0.739
Data Source:  STRINGDB
CRX
Tbio
Family:  TF
Novelty:  0.00278097
Score:  0.711
Data Source:  STRINGDB
SELPLG
Tbio
Novelty:  0.0016359
Score:  0.668
Data Source:  STRINGDB
PPT2
Tbio
Family:  Enzyme
Novelty:  0.00829249
Score:  0.639
Data Source:  STRINGDB
NMNAT1
Tbio
Family:  Enzyme
Novelty:  0.01110899
Score:  0.622
Data Source:  STRINGDB
GABBR1
Tclin
Family:  GPCR
Novelty:  0.00086493
Score:  0.609
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
2
2
58.9
mean corpuscular hemoglobin concentration
1
1
1
40.7
platelet count
1
1
1
36.9
heel bone mineral density
1
1
1
31.4
insomnia measurement
1
1
0
1
26.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
58.9
mean corpuscular hemoglobin concentration
1
40.7
platelet count
1
36.9
heel bone mineral density
1
31.4
insomnia measurement
0
1
26.6
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pleckstrin homology domain containing B1
VGNC:3065
748454
Macaque
pleckstrin homology domain containing B1
718702
Mouse
MGI:1351469
27276
Rat
RGD:621614
64471
Dog
pleckstrin homology domain containing B1
VGNC:44672
608340
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pleckstrin homology domain containing B1
Macaque
pleckstrin homology domain containing B1
Mouse
Rat
Dog
pleckstrin homology domain containing B1
Publication Statistics
PubMed Score 88.17
PubMed score by year
PubTator Score 45.04
PubTator score by year
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Related Publications
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PMID
Year
Title