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Tbio
PLEKHA5
Pleckstrin homology domain-containing family A member 5

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299275
  • ENSP00000299275
  • ENSG00000052126
  • ENST00000424268
  • ENSP00000400411
  • ENST00000429027
  • ENSP00000404296
  • ENST00000538714
  • ENSP00000439673
  • ENST00000540972
  • ENSP00000439396

Symbol
  • KIAA1686
  • PEPP2
  • PEPP2
  • PEPP-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.85
kinase perturbation
0.84
virus perturbation
0.83
cell line
0.78
tissue sample
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.53   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.53   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
GINM1
Tdark
Novelty:  1.0701107
p_int:  0.999999963
p_ni:  1.2e-8
p_wrong:  2.5e-8
Score:  0.169
Data Source:  BioPlex,STRINGDB
CALML3
Tbio
Novelty:  0.0336689
p_int:  0.99963958
p_ni:  0.000360143
p_wrong:  2.77e-7
Score:  0.213
Data Source:  BioPlex,STRINGDB
SSSCA1
Tdark
Novelty:  0.53523038
p_int:  0.998976323
p_ni:  0.000954535
p_wrong:  0.000069142
Data Source:  BioPlex
IL17RA
Tclin
Novelty:  0.00416706
p_int:  0.998496403
p_ni:  0.001362669
p_wrong:  0.000140928
Score:  0.185
Data Source:  BioPlex,STRINGDB
PCED1A
Tdark
Family:  Enzyme
Novelty:  2.30981765
Score:  0.677
Data Source:  STRINGDB
SEMA4F
Tbio
Novelty:  0.00574057
Score:  0.648
Data Source:  STRINGDB
AEBP2
Tbio
Novelty:  0.05974483
Score:  0.581
Data Source:  STRINGDB
PDZD11
Tbio
Novelty:  0.09750858
Score:  0.58
Data Source:  STRINGDB
PLCXD3
Tdark
Novelty:  0.2326972
Score:  0.571
Data Source:  STRINGDB
C8orf59
Tdark
Novelty:  5.32637076
Score:  0.571
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Reactome
Synthesis of PIPs at the plasma membrane
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Synthesis of PIPs at the plasma membrane
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
35
chronic mountain sickness
1
1
0
2.5
29
gut microbiome measurement
1
1
0
5.7
24.5
age at first sexual intercourse measurement
1
1
1
21.5
diastolic blood pressure
1
1
1
12.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
35
chronic mountain sickness
0
2.5
29
gut microbiome measurement
0
5.7
24.5
age at first sexual intercourse measurement
1
21.5
diastolic blood pressure
1
12.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1923802
109135
Rat
RGD:621175
246237
Dog
pleckstrin homology domain containing A5
VGNC:44669
477679
Horse
pleckstrin homology domain containing A5
VGNC:21560
100067899
Opossum
pleckstrin homology domain containing A5
100011922
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
pleckstrin homology domain containing A5
Horse
pleckstrin homology domain containing A5
Opossum
pleckstrin homology domain containing A5
Publication Statistics
PubMed Score 10.53
PubMed score by year
PubTator Score 3.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title