Tbio PLEKHA4 Pleckstrin homology domain-containing family A member 4

Protein Summary

Description

Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides. This gene encodes a pleckstrin homology (PH) domain-containing protein. The PH domain is found near the N-terminus and contains a putative phosphatidylinositol 3, 4, 5-triphosphate-binding motif (PPBM). Elevated expression of this gene has been observed in some melanomas. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]

Uniprot Accession IDs

• Q9H4M7
• Q8N4M8
• Q8N658
• PH domain-containing family A member 4

Gene Name

• PLEKHA4

Ensembl ID

• ENST00000263265
• ENSP00000263265
• ENSG00000105559
• ENST00000355496
• ENSP00000347683

Symbol

• PEPP1
• PEPP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.98
transcription factor perturbation	0.88
kinase perturbation	0.66
tissue sample	0.66
transcription factor	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.66   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 109   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.66   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0