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Tbio
PLEKHA3
Pleckstrin homology domain-containing family A member 3

Protein Summary
Description
Involved in Golgi to cell surface membrane traffic. Induces membrane tubulation. Binds preferentially to phosphatidylinositol 4-phosphate (PtdIns4P).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234453
  • ENSP00000234453
  • ENSG00000116095

Symbol
  • FAPP1
  • FAPP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
histone modification site profile
0.75
tissue sample
0.73
transcription factor binding site profile
0.68
gene perturbation
0.56


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.5   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.5   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
HAL
Tbio
Family:  Enzyme
Novelty:  0.01504631
p_int:  0.999999978
p_wrong:  2.1e-8
Score:  0.325
Data Source:  BioPlex,STRINGDB
SEC23B
Tbio
Novelty:  0.02307622
p_int:  0.999374023
p_ni:  0.000613373
p_wrong:  0.000012604
Data Source:  BioPlex
ARF1
Tchem
Family:  Enzyme
Novelty:  0.00208554
Score:  0.967
Data Source:  Reactome,STRINGDB
GLTP
Tbio
Novelty:  0.01044466
Score:  0.816
Data Source:  STRINGDB
CEL
Tchem
Family:  Enzyme
Novelty:  0.00156761
Score:  0.8
Data Source:  STRINGDB
CPLX3
Tbio
Novelty:  0.07332857
Score:  0.75
Data Source:  STRINGDB
SACM1L
Tbio
Family:  Enzyme
Novelty:  0.00499867
Score:  0.671
Data Source:  STRINGDB
MOSPD1
Tdark
Novelty:  0.42155538
Score:  0.67
Data Source:  STRINGDB
SERPINA4
Tbio
Novelty:  0.00483207
Score:  0.668
Data Source:  STRINGDB
FKBP7
Tbio
Family:  Enzyme
Novelty:  0.00572565
Score:  0.647
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Reactome
Synthesis of PIPs at the plasma membrane
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Synthesis of PIPs at the plasma membrane
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
0
1.1
88.2
electrocardiography
1
2
5
82
aspartate aminotransferase measurement
1
1
0
8.1
65.6
heart function measurement
2
1
2
60.2
left ventricular diastolic function measurement
1
1
0
2
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
88.2
electrocardiography
5
82
aspartate aminotransferase measurement
0
8.1
65.6
heart function measurement
2
60.2
left ventricular diastolic function measurement
0
2
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pleckstrin homology domain containing A3
VGNC:14340
459780
Macaque
pleckstrin homology domain containing A3
703417
Mouse
MGI:1932515
83435
Rat
RGD:1305244
295674
Dog
pleckstrin homology domain containing A3
VGNC:53102
488425
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pleckstrin homology domain containing A3
Macaque
pleckstrin homology domain containing A3
Mouse
Rat
Dog
pleckstrin homology domain containing A3
Publication Statistics
PubMed Score 15.50
PubMed score by year
PubTator Score 9.15
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title