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Tbio
PLEKHA2
Pleckstrin homology domain-containing family A member 2

Protein Summary
Description
Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000420274
  • ENSP00000393860
  • ENSG00000169499

Symbol
  • TAPP2
  • TAPP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
small molecule perturbation
0.8
transcription factor binding site profile
0.79
interacting protein
0.71
PubMedID
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.76   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.76   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
PTPN13
Tchem
Family:  Enzyme
Novelty:  0.00434963
Score:  0.942
Data Source:  Reactome,STRINGDB
KCTD16
Tbio
Novelty:  0.09898256
Score:  0.573
Data Source:  STRINGDB
PLEKHG1
Tbio
Novelty:  0.18355652
Score:  0.568
Data Source:  STRINGDB
INPPL1
Tchem
Family:  Enzyme
Novelty:  0.00634126
Score:  0.563
Data Source:  STRINGDB
GOT1L1
Tdark
Family:  Enzyme
Novelty:  0.52342415
Score:  0.555
Data Source:  STRINGDB
PLEKHH3
Tdark
Novelty:  2.43915121
Score:  0.545
Data Source:  STRINGDB
HTRA4
Tbio
Family:  Enzyme
Novelty:  0.09298487
Score:  0.538
Data Source:  STRINGDB
GIPC1
Tbio
Novelty:  0.00862
Score:  0.527
Data Source:  STRINGDB
TM2D2
Tdark
Novelty:  0.10390283
Score:  0.516
Data Source:  STRINGDB
OR2A14
Tdark
Family:  oGPCR
Novelty:  3.09310724
Score:  0.507
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Reactome
Synthesis of PIPs at the plasma membrane
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Synthesis of PIPs at the plasma membrane
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
brain measurement
1
1
0
7.2
46.3
monocyte percentage of leukocytes
1
1
1
37
monocyte count
1
1
1
30.9
basophil count
1
1
1
25.8
cortical surface area measurement
1
1
0
6
22.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
brain measurement
0
7.2
46.3
monocyte percentage of leukocytes
1
37
monocyte count
1
30.9
basophil count
1
25.8
cortical surface area measurement
0
6
22.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
pleckstrin homology domain containing A2
706470
Mouse
MGI:1928144
83436
Rat
RGD:1586710
684785
Dog
pleckstrin homology domain containing A2
VGNC:44668
482851
Horse
pleckstrin homology domain containing A2
VGNC:21557
100057530
Species
Name
OMA
EggNOG
Inparanoid
Macaque
pleckstrin homology domain containing A2
Mouse
Rat
Dog
pleckstrin homology domain containing A2
Horse
pleckstrin homology domain containing A2
Publication Statistics
PubMed Score 8.76
PubMed score by year
PubTator Score 5.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title