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Tbio
PLEKHA1
Pleckstrin homology domain-containing family A member 1

Protein Summary
Description
Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane. This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368988
  • ENSP00000357984
  • ENSG00000107679
  • ENST00000368990
  • ENSP00000357986
  • ENST00000392799
  • ENSP00000376547
  • ENST00000433307
  • ENSP00000394416

Symbol
  • TAPP1
  • TAPP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.85
interacting protein
0.76
biological process
0.75
transcription factor
0.75
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.27   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.27   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
LRRC61
Tdark
Novelty:  1.45343096
p_int:  0.999999977
p_ni:  2.2e-8
Data Source:  BioPlex
PPP1R15A
Tchem
Family:  Enzyme
Novelty:  0.00529607
p_int:  0.999997674
p_ni:  0.000002323
p_wrong:  3e-9
Score:  0.309
Data Source:  BioPlex,STRINGDB
MSL3
Tbio
Family:  Epigenetic
Novelty:  0.05711824
p_int:  0.999887153
p_ni:  0.000112626
p_wrong:  2.22e-7
Score:  0.282
Data Source:  BioPlex,STRINGDB
WDR45B
Tbio
Novelty:  0.22407227
p_int:  0.881786648
p_ni:  0.118213347
p_wrong:  4e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
PBX2
Tbio
Family:  TF
Novelty:  0.01339291
p_int:  0.847950292
p_ni:  0.15204104
p_wrong:  0.000008668
Score:  0.188
Data Source:  BioPlex,STRINGDB
PTPN13
Tchem
Family:  Enzyme
Novelty:  0.00434963
Score:  0.955
Data Source:  Reactome,STRINGDB
ARMS2
Tbio
Novelty:  0.00455168
Score:  0.804
Data Source:  STRINGDB
CFH
Tbio
Novelty:  0.00065547
Score:  0.636
Data Source:  STRINGDB
PTEN
Tchem
Family:  Enzyme
Novelty:  0.00013818
Score:  0.572
Data Source:  STRINGDB
PLEKHA3
Tbio
Novelty:  0.06598909
Score:  0.56
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Reactome
Synthesis of PIPs at the plasma membrane
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Synthesis of PIPs at the plasma membrane
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
15
9
1
2.2
99.8
5
3
0
2.3
98.2
atrophic macular degeneration
3
2
0
2.5
96.2
8
5
4
1.1
90.8
disease progression measurement
1
1
0
2.1
83
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
2.2
99.8
0
2.3
98.2
atrophic macular degeneration
0
2.5
96.2
4
1.1
90.8
disease progression measurement
0
2.1
83
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pleckstrin homology domain containing A1
VGNC:5660
450790
Macaque
pleckstrin homology domain containing A1
705731
Mouse
MGI:2442213
101476
Rat
RGD:1564153
361659
Dog
pleckstrin homology domain containing A1
VGNC:44667
477851
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pleckstrin homology domain containing A1
Macaque
pleckstrin homology domain containing A1
Mouse
Rat
Dog
pleckstrin homology domain containing A1
Publication Statistics
PubMed Score 25.27
PubMed score by year
PubTator Score 21.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title