Protein Summary
Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes (reviewed in PMID: 9701547, 11854008, and 17499243). Ple ...more
- ENST00000322810
- ENSP00000323856
- ENSG00000178209
- ENST00000345136
- ENSP00000344848
- ENST00000354589
- ENSP00000346602
- ENST00000354958
- ENSP00000347044
- ENST00000356346
- ENSP00000348702
- ENST00000357649
- ENSP00000350277
- ENST00000398774
- ENSP00000381756
- ENST00000436759
- ENSP00000388180
- ENST00000527096
- ENSP00000434583
- PLEC1
- HD1
- PCN
- EBS1
- EBSO
- PLTN
- EBSMD
- EBSND
- EBSOG
- EBSPA
- PLEC1
- LGMD2Q
- PLEC1b
- LGMDR17
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
hub protein | 1 | ||
ligand (protein) perturbation | 0.99 | ||
drug perturbation | 0.96 | ||
transcription factor binding site profile | 0.96 | ||
transcription factor perturbation | 0.91 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 480.03 (req: < 5)
Gene RIFs: 50 (req: <= 3)
Antibodies: 180 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 480.03 (req: >= 5)
Gene RIFs: 50 (req: > 3)
Antibodies: 180 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (381)
GSDME
Novelty: 0.01231123
p_int: 0.994392417
p_ni: 0.005607583
Score: 0.167
Data Source: BioPlex,STRINGDB
CCDC68
Novelty: 0.1262502
p_int: 0.992687381
p_ni: 0.007312619
Score: 0.201
Data Source: BioPlex,STRINGDB
NEFM
Novelty: 0.00239134
p_int: 0.991598474
p_ni: 0.008401526
Score: 0.305
Data Source: BioPlex,STRINGDB
GFOD1
Family: Enzyme
Novelty: 0.35031766
p_int: 0.957384589
p_ni: 0.042615411
Score: 0.166
Data Source: BioPlex,STRINGDB
SOCS6
Novelty: 0.00993375
p_int: 0.887467941
p_ni: 0.112532058
Score: 0.193
Data Source: BioPlex,STRINGDB
TFDP3
Family: TF
Novelty: 0.00223003
p_int: 0.879869728
p_ni: 0.120130272
Score: 0.195
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (18)
Reactome (11)
PathwayCommons (2)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Apoptosis | ||||
Reactome | Apoptotic cleavage of cellular proteins | ||||
Reactome | Apoptotic execution phase | ||||
Reactome | Assembly of collagen fibrils and other multimeric structures | ||||
Reactome | Caspase-mediated cleavage of cytoskeletal proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Apoptosis | ||||
Apoptotic cleavage of cellular proteins | ||||
Apoptotic execution phase | ||||
Assembly of collagen fibrils and other multimeric structures | ||||
Caspase-mediated cleavage of cytoskeletal proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (23)
Functions (7)
Components (13)
Processes (3)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (24)
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 9 | 8 | 11 | 96.6 | |||||
platelet count | 3 | 2 | 2 | 2.3 | 94.5 | ||||
mean corpuscular volume | 2 | 2 | 2 | 90.4 | |||||
total cholesterol measurement | 4 | 4 | 4 | 89.4 | |||||
apolipoprotein B measurement | 2 | 2 | 2 | 87.4 | |||||
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 11 | 96.6 | |||||
platelet count | 2 | 2.3 | 94.5 | ||||
mean corpuscular volume | 2 | 90.4 | |||||
total cholesterol measurement | 4 | 89.4 | |||||
apolipoprotein B measurement | 2 | 87.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | plectin | VGNC:821 | 464454 | |||||
Macaque | plectin | 699517 | ||||||
Mouse | MGI:1277961 | 18810 | ||||||
Rat | RGD:621649 | 64204 | ||||||
Dog | plectin | VGNC:44665 | 482083 | |||||
Publication Statistics
PubMed Score 480.03
PubMed score by year
PubTator Score 262.31
PubTator score by year
Related Publications
Text Mined References (114)
GeneRif Annotations (50)
Items per page:
0 of 0
PMID | Year | Title |
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