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Tbio
PLEC
Plectin

Protein Summary
Description
Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes (reviewed in PMID: 9701547, 11854008, and 17499243). Ple ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322810
  • ENSP00000323856
  • ENSG00000178209
  • ENST00000345136
  • ENSP00000344848
  • ENST00000354589
  • ENSP00000346602
  • ENST00000354958
  • ENSP00000347044
  • ENST00000356346
  • ENSP00000348702
  • ENST00000357649
  • ENSP00000350277
  • ENST00000398774
  • ENSP00000381756
  • ENST00000436759
  • ENSP00000388180
  • ENST00000527096
  • ENSP00000434583

Symbol
  • PLEC1
  • HD1
  • PCN
  • EBS1
  • EBSO
  • PLTN
  • EBSMD
  • EBSND
  • EBSOG
  • EBSPA
  • PLEC1
  • LGMD2Q
  • PLEC1b
  • LGMDR17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
ligand (protein) perturbation
0.99
drug perturbation
0.96
transcription factor binding site profile
0.96
transcription factor perturbation
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 551.2   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 551.2   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0