Tchem PLD2 Phospholipase D2

Protein Summary

Description

May have a role in signal-induced cytoskeletal regulation and/or endocytosis. The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

Uniprot Accession IDs

• O14939
• I3L2C9
• O43540
• O43579
• O43580
• Q6PGR0
• Q96BY3
• PLD 2

Gene Name

• PLD2

Ensembl ID

• ENST00000263088
• ENSP00000263088
• ENSG00000129219
• ENST00000572940
• ENSP00000459571

Symbol

• PLD1C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
metabolite	0.96
protein domain	0.92
kinase	0.9
hub protein	0.85
biological term	0.8

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 370.32   (req: < 5)

Gene RIFs: 117   (req: <= 3)

Antibodies: 245   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 370.32   (req: >= 5)

Gene RIFs: 117   (req: > 3)

Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 89

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0