Protein Summary
May have a role in signal-induced cytoskeletal regulation and/or endocytosis. The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
- ENST00000263088
- ENSP00000263088
- ENSG00000129219
- ENST00000572940
- ENSP00000459571
- PLD1C
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
metabolite | 0.96 | ||
protein domain | 0.92 | ||
kinase | 0.9 | ||
hub protein | 0.85 | ||
biological term | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 344.89 (req: < 5)
Gene RIFs: 102 (req: <= 3)
Antibodies: 245 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 344.89 (req: >= 5)
Gene RIFs: 102 (req: > 3)
Antibodies: 245 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 89
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (89)
Protein-Protein Interactions (230)
CHRM3
Family: GPCR
Novelty: 0.00849776
p_int: 0.995630811
p_ni: 0.004369189
Score: 0.307
Data Source: BioPlex,STRINGDB
GPR156
Family: GPCR
Novelty: 0.39183023
p_int: 0.983789946
p_ni: 0.016210054
Score: 0.152
Data Source: BioPlex,STRINGDB
SPC24
Novelty: 0.03166479
p_int: 0.982206045
p_ni: 0.017793955
Score: 0.166
Data Source: BioPlex,STRINGDB
CDH8
Novelty: 0.04055999
p_int: 0.973156279
p_ni: 0.026843721
Score: 0.163
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (5)
Upstream (4)
Downstream (1)
1 – 4 of 4
Pathways (152)
Reactome (10)
KEGG (13)
PathwayCommons (17)
WikiPathways (112)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Fcgamma receptor (FCGR) dependent phagocytosis | ||||
Reactome | Glycerophospholipid biosynthesis | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Fcgamma receptor (FCGR) dependent phagocytosis | ||||
Glycerophospholipid biosynthesis | ||||
Immune System | ||||
Innate Immune System | ||||
Metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (15)
Functions (3)
Components (4)
Processes (8)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (19)
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
lymphocyte count | 3 | 4 | 5 | 95.7 | |||||
blood metabolite measurement | 2 | 2 | 2 | 89 | |||||
C-X-C motif chemokine 16 measurement | 1 | 2 | 2 | 89 | |||||
sphingomyelin measurement | 1 | 2 | 6 | 86.4 | |||||
platelet count | 1 | 1 | 1 | 85.4 | |||||
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
lymphocyte count | 5 | 95.7 | |||||
blood metabolite measurement | 2 | 89 | |||||
C-X-C motif chemokine 16 measurement | 2 | 89 | |||||
sphingomyelin measurement | 6 | 86.4 | |||||
platelet count | 1 | 85.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | phospholipase D2 | VGNC:9528 | 454454 | |||||
Macaque | phospholipase D2 | 721573 | ||||||
Mouse | MGI:892877 | 18806 | ||||||
Rat | RGD:3350 | 25097 | ||||||
Dog | phospholipase D2 | VGNC:44661 | 479473 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | phospholipase D2 | |||||
Macaque | phospholipase D2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | phospholipase D2 | |||||
Publication Statistics
PubMed Score 344.89
PubMed score by year
PubTator Score 150.55
PubTator score by year
Related Publications
Text Mined References (141)
GeneRif Annotations (102)
Items per page:
0 of 0
PMID | Year | Title |
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