Protein Summary
May have a role in signal-induced cytoskeletal regulation and/or endocytosis. The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
- ENST00000263088
- ENSP00000263088
- ENSG00000129219
- ENST00000572940
- ENSP00000459571
- PLD1C
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
metabolite | 0.96 | ||
protein domain | 0.92 | ||
kinase | 0.9 | ||
hub protein | 0.85 | ||
biological term | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 344.89 (req: < 5)
Gene RIFs: 102 (req: <= 3)
Antibodies: 245 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 344.89 (req: >= 5)
Gene RIFs: 102 (req: > 3)
Antibodies: 245 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 89
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (89)
Protein-Protein Interactions (230)
CHRM3
Family: GPCR
Novelty: 0.00849776
p_int: 0.995630811
p_ni: 0.004369189
Score: 0.307
Data Source: BioPlex,STRINGDB
GPR156
Family: GPCR
Novelty: 0.39183023
p_int: 0.983789946
p_ni: 0.016210054
Score: 0.152
Data Source: BioPlex,STRINGDB
SPC24
Novelty: 0.03166479
p_int: 0.982206045
p_ni: 0.017793955
Score: 0.166
Data Source: BioPlex,STRINGDB
CDH8
Novelty: 0.04055999
p_int: 0.973156279
p_ni: 0.026843721
Score: 0.163
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (5)
Upstream (4)
Downstream (1)
1 – 4 of 4
Pathways (152)
Reactome (10)
KEGG (13)
PathwayCommons (17)
WikiPathways (112)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Fcgamma receptor (FCGR) dependent phagocytosis | ||||
Reactome | Glycerophospholipid biosynthesis | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Fcgamma receptor (FCGR) dependent phagocytosis | ||||
Glycerophospholipid biosynthesis | ||||
Immune System | ||||
Innate Immune System | ||||
Metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (15)
Functions (3)
Components (4)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (19)
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
lymphocyte count | 3 | 4 | 5 | 95.7 | |||||
blood metabolite measurement | 2 | 2 | 2 | 89 | |||||
C-X-C motif chemokine 16 measurement | 1 | 2 | 2 | 89 | |||||
sphingomyelin measurement | 1 | 2 | 6 | 86.4 | |||||
platelet count | 1 | 1 | 1 | 85.4 | |||||
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
lymphocyte count | 5 | 95.7 | |||||
blood metabolite measurement | 2 | 89 | |||||
C-X-C motif chemokine 16 measurement | 2 | 89 | |||||
sphingomyelin measurement | 6 | 86.4 | |||||
platelet count | 1 | 85.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | phospholipase D2 | VGNC:9528 | 454454 | |||||
Macaque | phospholipase D2 | 721573 | ||||||
Mouse | MGI:892877 | 18806 | ||||||
Rat | RGD:3350 | 25097 | ||||||
Dog | phospholipase D2 | VGNC:44661 | 479473 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | phospholipase D2 | |||||
Macaque | phospholipase D2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | phospholipase D2 | |||||
Publication Statistics
PubMed Score 344.89
PubMed score by year
PubTator Score 150.55
PubTator score by year
Related Publications
Text Mined References (141)
GeneRif Annotations (102)
Items per page:
0 of 0
PMID | Year | Title |
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