Tchem PLD1 Phospholipase D1

Protein Summary

Description

Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). This gene encodes a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking. Alternative splicing results in multiple transcript variants with both catalytic and regulatory properties. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• Q13393
• PLD 1

Gene Name

• PLD1

Ensembl ID

• ENST00000351298
• ENSP00000342793
• ENSG00000075651
• ENST00000356327
• ENSP00000348681

Symbol

• CVDD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
metabolite	0.96
protein domain	0.92
PubMedID	0.88
transcription factor binding site profile	0.84
histone modification site profile	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 217.28   (req: < 5)

Gene RIFs: 130   (req: <= 3)

Antibodies: 262   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 217.28   (req: >= 5)

Gene RIFs: 130   (req: > 3)

Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 100

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0