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Tbio
PLCL2
Inactive phospholipase C-like protein 2

Protein Summary
Description
May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000432376
  • ENSP00000412836
  • ENSG00000154822
  • ENST00000615277
  • ENSP00000478458
  • ENST00000638327
  • ENSP00000491897
  • ENSG00000284017
  • ENST00000638466
  • ENSP00000492839

Symbol
  • KIAA1092
  • PLCE2
  • PLCE2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
trait
0.97
kinase perturbation
0.93
transcription factor
0.76
virus perturbation
0.76


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.87   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.87   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (20)
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
p_int:  0.999999973
p_ni:  3e-9
p_wrong:  2.3e-8
Score:  0.582
Data Source:  BioPlex,STRINGDB
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  0.99999937
p_ni:  5.75e-7
p_wrong:  5.5e-8
Score:  0.583
Data Source:  BioPlex,STRINGDB
PPIL3
Tbio
Family:  Enzyme
Novelty:  0.09773948
p_int:  0.997486978
p_ni:  1.2e-8
p_wrong:  0.002513011
Data Source:  BioPlex
CASP1
Tchem
Family:  Enzyme
Novelty:  0.00034643
p_int:  0.992573304
p_ni:  0.000024811
p_wrong:  0.007401885
Score:  0.359
Data Source:  BioPlex,STRINGDB
MTHFS
Tbio
Family:  Enzyme
Novelty:  0.02886872
p_int:  0.973434524
p_ni:  0.000085257
p_wrong:  0.026480219
Score:  0.685
Data Source:  BioPlex,STRINGDB
SLC35F5
Tdark
Family:  Transporter
Novelty:  0.53360993
Score:  0.617
Data Source:  STRINGDB
SHOC2
Tbio
Novelty:  0.01203957
Score:  0.616
Data Source:  STRINGDB
LRRC3B
Tbio
Novelty:  0.05929142
Score:  0.487
Data Source:  STRINGDB
TTC21A
Tdark
Novelty:  0.13604442
Score:  0.472
Data Source:  STRINGDB
ZNF530
Tdark
Family:  TF
Novelty:  1.28917655
Score:  0.471
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
Find Similar Targets
Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
miRNA regulation of prostate cancer signaling pathways
WikiPathways
miRNA regulation of prostate cancer signaling pathways
WikiPathways
miRNA regulation of prostate cancer signaling pathways
WikiPathways
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
WikiPathways
Androgen receptor signaling pathway
Name
Explore in Pharos
Explore in Source
miRNA regulation of prostate cancer signaling pathways
miRNA regulation of prostate cancer signaling pathways
miRNA regulation of prostate cancer signaling pathways
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
Androgen receptor signaling pathway
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (86)
Items per page:
1 – 5 of 86
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
4
4
95.5
mean reticulocyte volume
1
4
4
95.5
mean corpuscular volume
4
6
7
95.1
mean corpuscular volume
4
6
7
95.1
basophil count
2
2
2
92.9
Items per page:
1 – 5 of 86
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
4
95.5
mean reticulocyte volume
4
95.5
mean corpuscular volume
7
95.1
mean corpuscular volume
7
95.1
basophil count
2
92.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
phospholipase C like 2
695590
Mouse
MGI:1352756
224860
Rat
RGD:1305941
301173
Dog
phospholipase C like 2
VGNC:44655
485652
Horse
phospholipase C like 2
VGNC:21545
100063395
Species
Name
OMA
EggNOG
Inparanoid
Macaque
phospholipase C like 2
Mouse
Rat
Dog
phospholipase C like 2
Horse
phospholipase C like 2
Publication Statistics
PubMed Score 7.87
PubMed score by year
PubTator Score 2.22
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title