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Tbio
PLCD4
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4

Protein Summary
Description
Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation. This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer. [provided by RefSeq, Jan 2 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000417849
  • ENSP00000396942
  • ENSG00000115556
  • ENST00000450993
  • ENSP00000388631
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
metabolite
0.89
cellular component
0.68
tissue sample
0.66
pathway
0.65


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.95   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.95   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (112)
HSPA1A
Tchem
Novelty:  0.00069195
p_int:  0.999999096
p_ni:  9.04e-7
Data Source:  BioPlex
WDR70
Tdark
Novelty:  0.37521871
p_int:  0.999989393
p_ni:  0.000010591
p_wrong:  1.5e-8
Data Source:  BioPlex
LENG8
Tdark
Novelty:  0.66682078
p_int:  0.999986262
p_ni:  0.000013738
Data Source:  BioPlex
BRPF1
Tchem
Family:  Epigenetic
Novelty:  0.02524021
p_int:  0.999976036
p_ni:  0.000015909
p_wrong:  0.000008055
Data Source:  BioPlex
HNRNPLL
Tbio
Novelty:  0.0498467
p_int:  0.999886686
p_ni:  0.000113314
Data Source:  BioPlex
SNAPC4
Tbio
Family:  TF
Novelty:  0.09720791
p_int:  0.999791239
p_ni:  0.000208755
p_wrong:  6e-9
Data Source:  BioPlex
NAP1L3
Tbio
Novelty:  0.03907508
p_int:  0.999757338
p_ni:  0.000150146
p_wrong:  0.000092517
Data Source:  BioPlex
CUSTOS
Tdark
Novelty:  0.50471779
p_int:  0.999633473
p_ni:  0.00035288
p_wrong:  0.000013647
Data Source:  BioPlex
AFF4
Tbio
Family:  TF
Novelty:  0.02113896
p_int:  0.999429051
p_ni:  0.000570949
Data Source:  BioPlex
NOLC1
Tbio
Novelty:  0.01922261
p_int:  0.998765846
p_ni:  0.001234155
Data Source:  BioPlex
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
Pathways (42)
Inositol phosphate metabolism (R-HSA-1483249)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inositol phosphate metabolism
Reactome
Metabolism
Reactome
Synthesis of IP3 and IP4 in the cytosol
Name
Explore in Pharos
Explore in Source
Inositol phosphate metabolism
Metabolism
Synthesis of IP3 and IP4 in the cytosol
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
2
2
91.4
hemoglobin measurement
2
2
2
88.4
reticulocyte count
1
1
1
75.1
body mass index
2
1
2
58.4
body height
1
2
2
49.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
91.4
hemoglobin measurement
2
88.4
reticulocyte count
1
75.1
body mass index
2
58.4
body height
2
49.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase C delta 4
VGNC:2757
470647
Macaque
phospholipase C delta 4
699569
Mouse
MGI:107469
18802
Rat
RGD:621025
140693
Dog
phospholipase C delta 4
VGNC:44649
478910
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase C delta 4
Macaque
phospholipase C delta 4
Mouse
Rat
Dog
phospholipase C delta 4
Publication Statistics
PubMed Score 12.95
PubMed score by year
PubTator Score 11.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title