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Tchem
PLCD1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

Protein Summary
Description
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development. This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334661
  • ENSP00000335600
  • ENSG00000187091
  • ENST00000463876
  • ENSP00000430344

Symbol
  • NDNC3
  • PLC-III
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor perturbation
0.96
molecular function
0.9
metabolite
0.89
disease perturbation
0.68


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.82   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.82   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (119)
FBXL4
Tbio
Novelty:  0.04286856
p_int:  0.999997624
p_ni:  0.000002375
Data Source:  BioPlex
IL31RA
Tbio
Novelty:  0.00737445
p_int:  0.999964203
p_ni:  0.000035797
Data Source:  BioPlex
FBXO3
Tbio
Novelty:  0.01701102
p_int:  0.999849887
p_ni:  0.000149478
p_wrong:  6.36e-7
Data Source:  BioPlex
GDF5
Tbio
Novelty:  0.00218118
p_int:  0.999833447
p_ni:  0.000165333
p_wrong:  0.00000122
Data Source:  BioPlex
RAB11B
Tbio
Family:  Enzyme
Novelty:  0.00557558
p_int:  0.999681519
p_ni:  0.00031799
p_wrong:  4.91e-7
Score:  0.152
Data Source:  BioPlex,STRINGDB
TEX35
Tdark
Novelty:  0.5605055
p_int:  0.999484001
p_ni:  0.000515957
p_wrong:  4.2e-8
Data Source:  BioPlex
PYHIN1
Tbio
Novelty:  0.06662677
p_int:  0.997515168
p_ni:  0.002476518
p_wrong:  0.000008314
Score:  0.177
Data Source:  BioPlex,STRINGDB
GPBP1
Tbio
Novelty:  0.18802498
p_int:  0.997439809
p_ni:  0.002559935
p_wrong:  2.55e-7
Score:  0.173
Data Source:  BioPlex,STRINGDB
USP6NL
Tbio
Novelty:  0.09667588
p_int:  0.997365975
p_ni:  0.002260072
p_wrong:  0.000373954
Data Source:  BioPlex
RBM24
Tbio
Novelty:  0.04562076
p_int:  0.992291999
p_ni:  0.000235523
p_wrong:  0.007472478
Data Source:  BioPlex
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
Pathways (29)
Inositol phosphate metabolism (R-HSA-1483249)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inositol phosphate metabolism
Reactome
Metabolism
Reactome
Synthesis of IP3 and IP4 in the cytosol
Name
Explore in Pharos
Explore in Source
Inositol phosphate metabolism
Metabolism
Synthesis of IP3 and IP4 in the cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
1
2
80.2
hemoglobin measurement
2
1
2
80.2
lymphocyte count
2
2
2
60.8
monocyte count
1
1
1
58.4
BMI-adjusted hip circumference
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
80.2
hemoglobin measurement
2
80.2
lymphocyte count
2
60.8
monocyte count
1
58.4
BMI-adjusted hip circumference
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase C delta 1
VGNC:2508
460267
Macaque
phospholipase C delta 1
696860
Mouse
MGI:97614
18799
Rat
RGD:3346
24655
Dog
phospholipase C delta 1
VGNC:44647
485586
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase C delta 1
Macaque
phospholipase C delta 1
Mouse
Rat
Dog
phospholipase C delta 1
Publication Statistics
PubMed Score 126.82
PubMed score by year
PubTator Score 115.18
PubTator score by year
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Related Publications
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PMID
Year
Title