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Tbio
PLCB3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

Protein Summary
Description
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000279230
  • ENSP00000279230
  • ENSG00000149782
  • ENST00000325234
  • ENSP00000324660
  • ENST00000540288
  • ENSP00000443631
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
pathway
0.91
metabolite
0.89
kinase
0.82
cell line
0.71


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.1   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 357   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.1   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 357   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (313)
SLC9A3R2
Tbio
Family:  Transporter
Novelty:  0.01401705
p_int:  1
Score:  0.951
Data Source:  BioPlex,STRINGDB
MAG
Tchem
Novelty:  0.00085621
p_int:  0.999958633
p_ni:  0.000034797
p_wrong:  0.000006571
Data Source:  BioPlex
GNAQ
Tbio
Novelty:  0.0008997
Score:  0.965
Data Source:  Reactome,STRINGDB
LPAR2
Tchem
Family:  GPCR
Novelty:  0.00794134
Score:  0.951
Data Source:  STRINGDB
ITPR3
Tchem
Family:  IC
Novelty:  0.00154917
Score:  0.95
Data Source:  STRINGDB
GNA11
Tchem
Novelty:  0.00128664
Score:  0.95
Data Source:  Reactome,STRINGDB
ITPR1
Tchem
Family:  IC
Novelty:  0.00111834
Score:  0.949
Data Source:  STRINGDB
GNAI2
Tchem
Novelty:  0.03014729
Score:  0.94
Data Source:  STRINGDB
GNAI1
Tbio
Novelty:  0.0488971
Score:  0.94
Data Source:  STRINGDB
CHRM1
Tclin
Family:  GPCR
Novelty:  0.00427119
Score:  0.939
Data Source:  STRINGDB
Nearest Tclin Targets (28)
Explore Nearest Tclin Targets
Pathways (118)
Acetylcholine regulates insulin secretion (R-HSA-399997)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine regulates insulin secretion
Reactome
Activation of kainate receptors upon glutamate binding
Reactome
Beta-catenin independent WNT signaling
Reactome
Ca2+ pathway
Reactome
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Name
Explore in Pharos
Explore in Source
Acetylcholine regulates insulin secretion
Activation of kainate receptors upon glutamate binding
Beta-catenin independent WNT signaling
Ca2+ pathway
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (52)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
3
8
9
97.5
BMI-adjusted waist-hip ratio
6
8
12
97.5
triglyceride measurement
4
3
4
93.5
urate measurement
1
4
4
93.2
high density lipoprotein cholesterol measurement
5
3
5
92.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
9
97.5
BMI-adjusted waist-hip ratio
12
97.5
triglyceride measurement
4
93.5
urate measurement
4
93.2
high density lipoprotein cholesterol measurement
5
92.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase C beta 3
VGNC:3067
451290
Macaque
phospholipase C beta 3
717764
Mouse
MGI:104778
18797
Rat
RGD:61993
29322
Dog
phospholipase C beta 3
VGNC:52035
476034
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase C beta 3
Macaque
phospholipase C beta 3
Mouse
Rat
Dog
phospholipase C beta 3
Publication Statistics
PubMed Score 59.10
PubMed score by year
PubTator Score 70.02
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title