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Tbio
PLCB1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Protein Summary
Description
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338037
  • ENSP00000338185
  • ENSG00000182621
  • ENST00000378637
  • ENSP00000367904
  • ENST00000378641
  • ENSP00000367908

Symbol
  • KIAA0581
  • PLC-I
  • EIEE12
  • PI-PLC
  • PLC154
  • PLCB1A
  • PLCB1B
  • PLC-154
  • PLC-beta-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
protein domain
0.99
molecular function
0.98
transcription factor perturbation
0.91
metabolite
0.89


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 413.84   (req: < 5)
Gene RIFs: 57   (req: <= 3)
Antibodies: 251   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 413.84   (req: >= 5)
Gene RIFs: 57   (req: > 3)
Antibodies: 251   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (343)
BTN2A1
Tbio
Novelty:  0.02259329
p_int:  0.999955201
p_ni:  0.000034638
p_wrong:  0.000010161
Score:  0.187
Data Source:  BioPlex,STRINGDB
PTGER3
Tclin
Family:  GPCR
Novelty:  0.0012681
p_int:  0.999936935
p_ni:  0.000023609
p_wrong:  0.000039456
Score:  0.23
Data Source:  BioPlex,STRINGDB
DEF8
Tbio
Novelty:  0.21146806
p_int:  0.999864744
p_ni:  0.000034933
p_wrong:  0.000100323
Score:  0.189
Data Source:  BioPlex,STRINGDB
GNAQ
Tbio
Novelty:  0.0008997
Score:  0.99
Data Source:  Reactome,STRINGDB
PRKCA
Tchem
Family:  Kinase
Novelty:  0.00057611
Score:  0.981
Data Source:  STRINGDB
ITPR2
Tbio
Family:  IC
Novelty:  0.00619813
Score:  0.963
Data Source:  STRINGDB
GNA11
Tchem
Novelty:  0.00128664
Score:  0.961
Data Source:  Reactome,STRINGDB
ITPR1
Tchem
Family:  IC
Novelty:  0.00111834
Score:  0.956
Data Source:  STRINGDB
ITPR3
Tchem
Family:  IC
Novelty:  0.00154917
Score:  0.954
Data Source:  STRINGDB
GRM5
Tchem
Family:  GPCR
Novelty:  0.00062552
Score:  0.95
Data Source:  STRINGDB
Nearest Tclin Targets (28)
Explore Nearest Tclin Targets
Pathways (118)
Acetylcholine regulates insulin secretion (R-HSA-399997)

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Find Similar Targets
Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine regulates insulin secretion
Reactome
Activation of kainate receptors upon glutamate binding
Reactome
Beta-catenin independent WNT signaling
Reactome
Ca2+ pathway
Reactome
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Name
Explore in Pharos
Explore in Source
Acetylcholine regulates insulin secretion
Activation of kainate receptors upon glutamate binding
Beta-catenin independent WNT signaling
Ca2+ pathway
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (53)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
AgBase
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (34)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
2
2
85.2
monocyte count
3
2
3
84.6
lymphocyte count
4
2
4
83.8
platelet count
3
3
3
82.9
leukocyte count
3
3
4
82.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
85.2
monocyte count
3
84.6
lymphocyte count
4
83.8
platelet count
3
82.9
leukocyte count
4
82.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase C beta 1
VGNC:6242
469875
Macaque
phospholipase C beta 1
718387
Mouse
MGI:97613
18795
Rat
RGD:3344
24654
Dog
phospholipase C beta 1
VGNC:44644
485773
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase C beta 1
Macaque
phospholipase C beta 1
Mouse
Rat
Dog
phospholipase C beta 1
Publication Statistics
PubMed Score 413.84
PubMed score by year
PubTator Score 384.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title