Protein Summary
In view of the small size of the putative binding pocket, it has been proposed that it may act as an amidase or a peptidase (By similarity). Exhibits a weak phospholipase activity, acting on various phospholipids, including phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and lysophospholipids.
- ENST00000240617
- ENSP00000240617
- ENSG00000121316
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.99 | ||
transcription factor perturbation | 0.94 | ||
PubMedID | 0.82 | ||
disease perturbation | 0.74 | ||
histone modification site profile | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.21 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 62 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.21 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 62 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (25)
PI4KA
Family: Kinase
Novelty: 0.01701469
p_int: 0.999948187
p_ni: 0.000051812
Data Source: BioPlex
ZIC1
Family: TF
Novelty: 0.00491601
p_int: 0.999940538
p_ni: 0.000059462
p_wrong: 1e-9
Data Source: BioPlex
TBC1D22B
Novelty: 0.49852962
p_int: 0.999883576
p_ni: 0.000116421
p_wrong: 3e-9
Data Source: BioPlex
GMCL1
Novelty: 0.1543762
p_int: 0.999869669
p_ni: 0.000130175
p_wrong: 1.56e-7
Data Source: BioPlex
CCDC51
Novelty: 1.19203634
p_int: 0.9996655
p_ni: 0.0003345
Score: 0.191
Data Source: BioPlex,STRINGDB
VAV1
Novelty: 0.00180518
p_int: 0.999614801
p_ni: 0.000385197
p_wrong: 2e-9
Score: 0.206
Data Source: BioPlex,STRINGDB
GPATCH2L
Novelty: 1.68490464
p_int: 0.999601553
p_ni: 0.000398447
Score: 0.157
Data Source: BioPlex,STRINGDB
FTH1
Novelty: 0.000863
p_int: 0.998380998
p_ni: 0.00157675
p_wrong: 0.000042252
Data Source: BioPlex
IL31RA
Novelty: 0.00737445
p_int: 0.998297289
p_ni: 0.001660125
p_wrong: 0.000042585
Data Source: BioPlex
SPICE1
Novelty: 0.19045168
p_int: 0.975555026
p_ni: 0.024444448
p_wrong: 5.26e-7
Score: 0.211
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (8)
Reactome (8)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Acyl chain remodelling of PC | ||||
Reactome | Acyl chain remodelling of PE | ||||
Reactome | Acyl chain remodelling of PI | ||||
Reactome | Glycerophospholipid biosynthesis | ||||
Reactome | Hydrolysis of LPC | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Acyl chain remodelling of PC | ||||
Acyl chain remodelling of PE | ||||
Acyl chain remodelling of PI | ||||
Glycerophospholipid biosynthesis | ||||
Hydrolysis of LPC | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (2)
Components (3)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations (null)
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
self reported educational attainment | 3 | 3 | 2 | 5.9 | 73.2 | ||||
mathematical ability | 1 | 1 | 1 | 68.6 | |||||
intelligence | 2 | 2 | 1 | 5.9 | 66.6 | ||||
cognitive function measurement | 1 | 1 | 1 | 61 | |||||
2 | 1 | 0 | 1.3 | 59 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
self reported educational attainment | 2 | 5.9 | 73.2 | ||||
mathematical ability | 1 | 68.6 | |||||
intelligence | 1 | 5.9 | 66.6 | ||||
cognitive function measurement | 1 | 61 | |||||
0 | 1.3 | 59 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | phospholipase B domain containing 1 | VGNC:5534 | 465304 | |||||
Macaque | phospholipase B domain containing 1 | 698939 | ||||||
Mouse | MGI:1914107 | 66857 | ||||||
Rat | RGD:1308734 | 297694 | ||||||
Dog | phospholipase B domain containing 1 | VGNC:44642 | 486673 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | phospholipase B domain containing 1 | |||||
Macaque | phospholipase B domain containing 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | phospholipase B domain containing 1 | |||||
Publication Statistics
PubMed Score 3.21
PubMed score by year
PubTator Score 0.38
PubTator score by year
Related Publications
Text Mined References (6)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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