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Tdark
PLBD1
Phospholipase B-like 1

Protein Summary
Description
In view of the small size of the putative binding pocket, it has been proposed that it may act as an amidase or a peptidase (By similarity). Exhibits a weak phospholipase activity, acting on various phospholipids, including phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and lysophospholipids.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000240617
  • ENSP00000240617
  • ENSG00000121316
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
transcription factor perturbation
0.94
PubMedID
0.82
disease perturbation
0.74
histone modification site profile
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.21   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.21   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (25)
PI4KA
Tchem
Family:  Kinase
Novelty:  0.01701469
p_int:  0.999948187
p_ni:  0.000051812
Data Source:  BioPlex
ZIC1
Tbio
Family:  TF
Novelty:  0.00491601
p_int:  0.999940538
p_ni:  0.000059462
p_wrong:  1e-9
Data Source:  BioPlex
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.999883576
p_ni:  0.000116421
p_wrong:  3e-9
Data Source:  BioPlex
GMCL1
Tbio
Novelty:  0.1543762
p_int:  0.999869669
p_ni:  0.000130175
p_wrong:  1.56e-7
Data Source:  BioPlex
CCDC51
Tdark
Novelty:  1.19203634
p_int:  0.9996655
p_ni:  0.0003345
Score:  0.191
Data Source:  BioPlex,STRINGDB
VAV1
Tchem
Novelty:  0.00180518
p_int:  0.999614801
p_ni:  0.000385197
p_wrong:  2e-9
Score:  0.206
Data Source:  BioPlex,STRINGDB
GPATCH2L
Tdark
Novelty:  1.68490464
p_int:  0.999601553
p_ni:  0.000398447
Score:  0.157
Data Source:  BioPlex,STRINGDB
FTH1
Tbio
Novelty:  0.000863
p_int:  0.998380998
p_ni:  0.00157675
p_wrong:  0.000042252
Data Source:  BioPlex
IL31RA
Tbio
Novelty:  0.00737445
p_int:  0.998297289
p_ni:  0.001660125
p_wrong:  0.000042585
Data Source:  BioPlex
SPICE1
Tbio
Novelty:  0.19045168
p_int:  0.975555026
p_ni:  0.024444448
p_wrong:  5.26e-7
Score:  0.211
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Acyl chain remodelling of PC (R-HSA-1482788)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodelling of PC
Reactome
Acyl chain remodelling of PE
Reactome
Acyl chain remodelling of PI
Reactome
Glycerophospholipid biosynthesis
Reactome
Hydrolysis of LPC
Name
Explore in Pharos
Explore in Source
Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Glycerophospholipid biosynthesis
Hydrolysis of LPC
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
3
2
5.9
73.2
mathematical ability
1
1
1
68.6
intelligence
2
2
1
5.9
66.6
cognitive function measurement
1
1
1
61
2
1
0
1.3
59
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
5.9
73.2
mathematical ability
1
68.6
intelligence
1
5.9
66.6
cognitive function measurement
1
61
0
1.3
59
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase B domain containing 1
VGNC:5534
465304
Macaque
phospholipase B domain containing 1
698939
Mouse
MGI:1914107
66857
Rat
RGD:1308734
297694
Dog
phospholipase B domain containing 1
VGNC:44642
486673
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase B domain containing 1
Macaque
phospholipase B domain containing 1
Mouse
Rat
Dog
phospholipase B domain containing 1
Publication Statistics
PubMed Score 3.21
PubMed score by year
PubTator Score 0.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title