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Tbio
PLB1
Phospholipase B1, membrane-associated

Protein Summary
Description
Membrane-associated phospholipase. Exhibits a calcium-independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids (By similarity). This gene encodes a membrane-associated phospholipase that displays lysophospholipase and phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays lipase and retinyl ester hydrolase activities. The encoded protein is highly conserved and is composed of a large, glycosylated extracellular domain composed of four tandem homologous domains, followed by a hydrophobic segment that anchors the enzyme to the membrane and a short C-terminal cytoplasmic tail. This gene has been i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327757
  • ENSP00000330442
  • ENSG00000163803
  • ENST00000422425
  • ENSP00000416440

Symbol
  • PLB
  • PLB
  • PLB/LIP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
1
trait
0.75
biological process
0.63
phenotype
0.59
virus perturbation
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.93   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.93   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (108)
CSGALNACT2
Tbio
Family:  Enzyme
Novelty:  0.0770692
p_int:  0.999888948
p_ni:  0.000111052
Score:  0.158
Data Source:  BioPlex,STRINGDB
MPO
Tchem
Family:  Enzyme
Novelty:  0.00020698
p_int:  0.999827172
p_ni:  0.00001532
p_wrong:  0.000157507
Score:  0.386
Data Source:  BioPlex,STRINGDB
IGHA2
Tbio
p_int:  0.998831482
p_ni:  0.00116846
p_wrong:  5.8e-8
Data Source:  BioPlex
WDR47
Tdark
Novelty:  0.51632776
p_int:  0.998499346
p_ni:  0.001500653
Score:  0.187
Data Source:  BioPlex,STRINGDB
DEFA1
Tbio
Novelty:  0.01027492
p_int:  0.910387987
p_ni:  0.000169375
p_wrong:  0.089442639
Score:  0.308
Data Source:  BioPlex,STRINGDB
IFI30
Tbio
Family:  Enzyme
Novelty:  0.00939681
p_int:  0.908210681
p_ni:  0.000122524
p_wrong:  0.091666795
Score:  0.22
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.871264879
p_ni:  0.128735121
Data Source:  BioPlex
CCT6B
Tdark
Novelty:  0.28933315
p_int:  0.786269437
p_ni:  0.213730563
Data Source:  BioPlex
LCAT
Tchem
Family:  Enzyme
Novelty:  0.00307544
Score:  0.923
Data Source:  STRINGDB
PLA2G16
Tchem
Novelty:  0.02310886
Score:  0.916
Data Source:  STRINGDB
Pathways (21)
Acyl chain remodelling of PC (R-HSA-1482788)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodelling of PC
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Acyl chain remodelling of PC
G alpha (i) signalling events
GPCR downstream signalling
Glycerophospholipid biosynthesis
Metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
3
3
92.9
heel bone mineral density
3
5
7
92.5
hair color
1
3
0
1.1
91
eosinophil percentage of leukocytes
2
2
2
87.6
triglyceride measurement
3
3
3
81.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
92.9
heel bone mineral density
7
92.5
hair color
0
1.1
91
eosinophil percentage of leukocytes
2
87.6
triglyceride measurement
3
81.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase B1
VGNC:335
459117
Macaque
phospholipase B1
100424557
Mouse
MGI:1922406
665270
Rat
RGD:621565
192259
Dog
phospholipase B1
VGNC:44641
611194
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase B1
Macaque
phospholipase B1
Mouse
Rat
Dog
phospholipase B1
Publication Statistics
PubMed Score 67.93
PubMed score by year
PubTator Score 65.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title