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Tchem
PLAU
Urokinase-type plasminogen activator

Protein Summary
Description
Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372764
  • ENSP00000361850
  • ENSG00000122861
  • ENST00000496777
  • ENSP00000431795

Symbol
  • ATF
  • QPD
  • UPA
  • URK
  • u-PA
  • BDPLT5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
protein domain
0.99
drug
0.97
virus perturbation
0.97
small molecule perturbation
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2217.75   (req: < 5)
Gene RIFs: 418   (req: <= 3)
Antibodies: 966   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2217.75   (req: >= 5)
Gene RIFs: 418   (req: > 3)
Antibodies: 966   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 490
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1