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Tchem
PLAA
Phospholipase A-2-activating protein

Protein Summary
Description
Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (PubMed:27753622). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). Plays a role in cerebellar Purkinje cell development (By similarity). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:18291623, PubMed:28007986).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397292
  • ENSP00000380460
  • ENSG00000137055

Symbol
  • PLAP
  • DOA1
  • PLAP
  • PLA2P
  • NDMSBA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
transcription factor perturbation
0.84
interacting protein
0.76
virus perturbation
0.76
transcription factor binding site profile
0.7


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.34   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 405   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.34   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 405   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (115)
CD79B
Tclin
Novelty:  0.00227414
p_int:  0.998363623
p_ni:  0.001636376
p_wrong:  1e-9
Data Source:  BioPlex
XXYLT1
Tbio
Family:  Enzyme
Novelty:  0.16837376
p_int:  0.997790087
p_ni:  0.002209913
Data Source:  BioPlex
LAMP1
Tbio
Novelty:  0.00067563
p_int:  0.996982699
p_ni:  0.003017301
Score:  0.183
Data Source:  BioPlex,STRINGDB
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.992039697
p_ni:  0.007960303
Data Source:  BioPlex
OR2G6
Tdark
Family:  oGPCR
p_int:  0.984705308
p_ni:  0.015294692
Data Source:  BioPlex
CD70
Tbio
Novelty:  0.00420393
p_int:  0.980418072
p_ni:  0.019581928
Data Source:  BioPlex
MILR1
Tbio
Novelty:  0.07477675
p_int:  0.980192643
p_ni:  0.019807357
Score:  0.23
Data Source:  BioPlex,STRINGDB
LYPD3
Tbio
Novelty:  0.03248533
p_int:  0.978823993
p_ni:  0.021176007
Data Source:  BioPlex
SIGLEC12
Tbio
Novelty:  0.00914453
p_int:  0.975476714
p_ni:  0.024523286
Score:  0.256
Data Source:  BioPlex,STRINGDB
SRPRB
Tbio
Novelty:  0.04735362
p_int:  0.936882743
p_ni:  0.063117257
Score:  0.162
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 activating protein
VGNC:9187
465026
Mouse
MGI:104810
18786
Rat
RGD:621245
116645
Dog
phospholipase A2 activating protein
VGNC:44634
474733
Horse
phospholipase A2 activating protein
VGNC:21521
100053453
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 activating protein
Mouse
Rat
Dog
phospholipase A2 activating protein
Horse
phospholipase A2 activating protein
Publication Statistics
PubMed Score 93.34
PubMed score by year
PubTator Score 117.17
PubTator score by year
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Related Publications
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PMID
Year
Title