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Tchem
PLA2G7
Platelet-activating factor acetylhydrolase

Protein Summary
Description
Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids. The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274793
  • ENSP00000274793
  • ENSG00000146070
  • ENST00000537365
  • ENSP00000445666

Symbol
  • PAFAH
  • PAFAD
  • PAFAH
  • LP-PLA2
  • LDL-PLA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.95
biological term
0.94
kinase perturbation
0.84
gene perturbation
0.77
transcription factor perturbation
0.74


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 629.42   (req: < 5)
Gene RIFs: 227   (req: <= 3)
Antibodies: 334   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 629.42   (req: >= 5)
Gene RIFs: 227   (req: > 3)
Antibodies: 334   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 354
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1