Tchem PLA2G6 85/88 kDa calcium-independent phospholipase A2

Protein Summary

Description

Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F-actin polymerization at the pseudopods. Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity. The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• O60733
• A8K597
• B0QYE8
• O75645
• Q8N452
• Q9UG29
• Q9UIT0
• Q9Y671
• CaI-PLA2

Gene Name

• PLA2G6

Ensembl ID

• ENST00000332509
• ENSP00000333142
• ENSG00000184381
• ENST00000335539
• ENSP00000335149
• ENST00000402064
• ENSP00000386100

Symbol

• PLPLA9
• GVI
• PLA2
• INAD1
• NBIA2
• iPLA2
• NBIA2A
• NBIA2B
• PARK14
• PNPLA9
• CaI-PLA2
• IPLA2-VIA
• iPLA2beta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
metabolite	0.94
disease perturbation	0.87
trait	0.86
transcription factor binding site profile	0.86

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / 85/88 Kda Calcium-independent Phospholipase A2

DTO Classes

Protein / Enzyme Modulator / 85/88 Kda Calcium-independent Phospholipase A2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 494.96   (req: < 5)

Gene RIFs: 134   (req: <= 3)

Antibodies: 221   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 494.96   (req: >= 5)

Gene RIFs: 134   (req: > 3)

Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0