You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
PLA2G4A
Cytosolic phospholipase A2

Protein Summary
Description
Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367466
  • ENSP00000356436
  • ENSG00000116711

Symbol
  • CPLA2
  • PLA2G4
  • GURDP
  • cPLA2
  • PLA2G4
  • cPLA2-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.99
interacting protein
0.99
metabolite
0.95
biological term
0.94
gene perturbation
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 703.77   (req: < 5)
Gene RIFs: 139   (req: <= 3)
Antibodies: 362   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 703.77   (req: >= 5)
Gene RIFs: 139   (req: > 3)
Antibodies: 362   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 169
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (169)
Arachidonic acid derivative
Rendered image for Arachidonic acid derivative
CHEMBL29838
Rendered image for CHEMBL29838
CHEMBL268905
Rendered image for CHEMBL268905
CHEMBL443834
Rendered image for CHEMBL443834
Efipladib
Rendered image for Efipladib
CHEMBL426665
Rendered image for CHEMBL426665
CHEMBL441326
Rendered image for CHEMBL441326
CHEMBL9161
Rendered image for CHEMBL9161
CHEMBL267258
Rendered image for CHEMBL267258
Protein-Protein Interactions (169)
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
Score:  0.971
Data Source:  Reactome,STRINGDB
MAPK3
Tchem
Family:  Kinase
Novelty:  0.00012969
Score:  0.969
Data Source:  STRINGDB
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.968
Data Source:  Reactome,STRINGDB
MKNK1
Tchem
Family:  Kinase
Novelty:  0.01445137
Score:  0.951
Data Source:  STRINGDB
PTGS2
Tclin
Family:  Enzyme
Novelty:  0.00007089
Score:  0.946
Data Source:  STRINGDB
MAP2K1
Tclin
Family:  Kinase
Novelty:  0.0005278
Score:  0.936
Data Source:  STRINGDB
SYK
Tclin
Family:  Kinase
Novelty:  0.00058994
Score:  0.934
Data Source:  STRINGDB
MAPK11
Tchem
Family:  Kinase
Novelty:  0.00545217
Score:  0.928
Data Source:  STRINGDB
LYN
Tclin
Family:  Kinase
Novelty:  0.00097393
Score:  0.925
Data Source:  STRINGDB
GNA14
Tbio
Novelty:  0.0587776
Score:  0.923
Data Source:  STRINGDB
Nearest Tclin Targets (5)
Explore Nearest Tclin Targets
Pathways (79)
ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 34
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 1
Reactome
Acyl chain remodeling of CL
Reactome
Acyl chain remodelling of PC
Reactome
Acyl chain remodelling of PE
Reactome
Acyl chain remodelling of PG
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 1
Acyl chain remodeling of CL
Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PG
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (33)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
30.2
glomerular filtration rate
1
1
1
9.5
urate measurement
1
1
1
9.4
blood urea nitrogen measurement
1
1
1
0.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
30.2
glomerular filtration rate
1
9.5
urate measurement
1
9.4
blood urea nitrogen measurement
1
0.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 group IVA
VGNC:9881
469617
Macaque
phospholipase A2 group IVA
716635
Mouse
MGI:1195256
18783
Rat
RGD:67366
24653
Dog
phospholipase A2 group IVA
VGNC:44626
480048
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 group IVA
Macaque
phospholipase A2 group IVA
Mouse
Rat
Dog
phospholipase A2 group IVA
Publication Statistics
PubMed Score 703.77
PubMed score by year
PubTator Score 707.07
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title