PLA2G2F
Group IIF secretory phospholipase A2
Protein Summary
May play a role in lipid mediator production in inflammatory conditions, by providing arachidonic acid to downstream cyclooxygenases and lipoxygenases (By similarity). Phospholipase A2, which catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (PubMed:11112443). Hydrolyzes phosphatidylethanolamine more efficiently than phosphatidylcholine, with only a modest preference for arachidonic acid versus linoelic acid at the sn-2 position. Comparable activity toward 1-palmitoyl-2-oleoyl-phosphatidylserine vesicles to that toward 1-palmitoyl-2-oleoyl-phosphatidylglycerol (By similarity). Hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference (PubMed:11112443).
- ENST00000375102
- ENSP00000364243
- ENSG00000158786
- GIIFsPLA2
- sPLA2-IIF
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
metabolite | 0.95 | ||
pathway | 0.59 | ||
microRNA | 0.58 | ||
cell type or tissue | 0.49 | ||
hub protein | 0.49 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2.89 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 2 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2.89 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 2 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 8
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (8)
Protein-Protein Interactions (65)
Nearest Tclin Targets (4)
Upstream (1)
Downstream (3)
1 – 1 of 1
Pathways (22)
Reactome (10)
KEGG (10)
PathwayCommons (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Acyl chain remodelling of PC | ||||
Reactome | Acyl chain remodelling of PE | ||||
Reactome | Acyl chain remodelling of PG | ||||
Reactome | Acyl chain remodelling of PI | ||||
Reactome | Acyl chain remodelling of PS | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Acyl chain remodelling of PC | ||||
Acyl chain remodelling of PE | ||||
Acyl chain remodelling of PG | ||||
Acyl chain remodelling of PI | ||||
Acyl chain remodelling of PS | ||||
Viral Interactions (0)
Gene Ontology Terms (20)
Functions (6)
Components (3)
Processes (11)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Disease Associations (null)
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
telomere length | 1 | 1 | 1 | 1.5 | |||||
polyunsaturated fatty acid measurement | 1 | 1 | 1 | 1.5 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
telomere length | 1 | 1.5 | |||||
polyunsaturated fatty acid measurement | 1 | 1.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | phospholipase A2 group IIF | VGNC:9880 | 748868 | |||||
Mouse | MGI:1349661 | 26971 | ||||||
Rat | RGD:1597305 | 690388 | ||||||
Dog | phospholipase A2 group IIF | VGNC:44624 | 487397 | |||||
Horse | phospholipase A2 group IIF | VGNC:21511 | 100071833 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | phospholipase A2 group IIF | |||||
Mouse | ||||||
Rat | ||||||
Dog | phospholipase A2 group IIF | |||||
Horse | phospholipase A2 group IIF | |||||
Publication Statistics
PubMed Score 2.89
PubMed score by year
PubTator Score 3.57
PubTator score by year
Related Publications
Text Mined References (7)
GeneRif Annotations (4)
Items per page:
0 of 0
PMID | Year | Title |
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