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Tchem
PLA2G2D
Group IID secretory phospholipase A2

Protein Summary
Description
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2-linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than the other phospholipids examined. This gene encodes a secreted member of the phospholipase A2 family, and is found in a cluster of related family members on chromosome 1. Phospholipase A2 family members hydrolyze the sn-2 fatty acid ester bond of glycerophospholipids to produce lysophospholipids and free fatty acid. This gene may be involved in inflammation and immune response, and in weight loss associated with chronic obstructive pulmonary disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375105
  • ENSP00000364246
  • ENSG00000117215

Symbol
  • SPLASH
  • SPLASH
  • sPLA2S
  • PLA2IID
  • sPLA2-IID
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.95
tissue sample
0.64
pathway
0.59
gene perturbation
0.53
cell line
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.11   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.11   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (10)
varespladib
Rendered image for varespladib
CHEMBL515637
Rendered image for CHEMBL515637
CHEMBL148649
Rendered image for CHEMBL148649
CHEMBL446349
Rendered image for CHEMBL446349
CHEMBL514692
Rendered image for CHEMBL514692
CHEMBL514841
Rendered image for CHEMBL514841
CHEMBL514705
Rendered image for CHEMBL514705
CHEMBL506485
Rendered image for CHEMBL506485
CHEMBL504813
Rendered image for CHEMBL504813
CHEMBL479251
Rendered image for CHEMBL479251
Protein-Protein Interactions (106)
PPM1A
Tchem
Family:  Enzyme
Novelty:  0.01464968
p_int:  0.999345693
p_ni:  0.0006543
p_wrong:  8e-9
Data Source:  BioPlex
TTC19
Tbio
Novelty:  0.08251578
p_int:  0.998930789
p_ni:  0.001069211
Data Source:  BioPlex
MMADHC
Tbio
Novelty:  0.02299238
p_int:  0.99652438
p_ni:  0.00336334
p_wrong:  0.00011228
Data Source:  BioPlex
NUCB2
Tbio
Novelty:  0.00831106
p_int:  0.992960043
p_ni:  0.007039957
Data Source:  BioPlex
ZZEF1
Tdark
Novelty:  0.33216648
p_int:  0.98563627
p_ni:  0.014363731
Data Source:  BioPlex
NUCB1
Tchem
Novelty:  0.0040312
p_int:  0.967617903
p_ni:  0.032382097
Data Source:  BioPlex
CAMK1
Tchem
Family:  Kinase
Novelty:  0.01239891
p_int:  0.933567759
p_ni:  0.066364238
p_wrong:  0.000068002
Data Source:  BioPlex
DCAF6
Tbio
Novelty:  0.01269552
p_int:  0.918678447
p_ni:  0.081321553
Data Source:  BioPlex
HEXA
Tchem
Family:  Enzyme
Novelty:  0.01134783
p_int:  0.900347878
p_ni:  0.099652122
Data Source:  BioPlex
FBLN1
Tbio
Novelty:  0.00796703
p_int:  0.890239161
p_ni:  0.109760839
Data Source:  BioPlex
Pathways (26)
Acyl chain remodelling of PC (R-HSA-1482788)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodelling of PC
Reactome
Acyl chain remodelling of PE
Reactome
Acyl chain remodelling of PG
Reactome
Acyl chain remodelling of PI
Reactome
Acyl chain remodelling of PS
Name
Explore in Pharos
Explore in Source
Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PG
Acyl chain remodelling of PI
Acyl chain remodelling of PS
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
1
1
1
1.5
polyunsaturated fatty acid measurement
1
1
1
1.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
1
1.5
polyunsaturated fatty acid measurement
1
1.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 group IID
VGNC:9879
469200
Macaque
phospholipase A2 group IID
704735
Mouse
MGI:1341796
18782
Rat
RGD:1309862
298579
Dog
phospholipase A2 group IID
VGNC:44623
487398
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 group IID
Macaque
phospholipase A2 group IID
Mouse
Rat
Dog
phospholipase A2 group IID
Publication Statistics
PubMed Score 74.11
PubMed score by year
PubTator Score 88.71
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title