Protein Summary
Lipid-modifying enzyme that acts as major regulator of adipocyte lipolysis by catalyzing the release of fatty acids from phospholipids in adipose tissue (PubMed:19615464, PubMed:19047760, PubMed:20837014, PubMed:22605381, PubMed:22923616). Shows phospholipase A1 and A2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE) (PubMed:19615464, PubMed:19047760, PubMed:20837014, PubMed:22605381, PubMed:22923616). For most substrates, phospholipase A1 activity is much higher than phospholipase A2 activity (PubMed:19047760). Phospholipase activity causes decreased intracellular levels of ether-type lipids, affecting peroxisome metabolism (By similarity). May also have acyltransferase activity: catalyzes both N-acylation of phosphatidylethanolamine to form N-acyl-phosphatidylethanolamine and O-acylation of lyso-phosphatidylcholines to form phosphatidylcholines (PubMed:22605381, PubMed:25383759). The relevanc ...more
- ENST00000323646
- ENSP00000320337
- ENSG00000176485
- ENST00000415826
- ENSP00000389124
- HRASLS3
- HREV107
- AdPLA
- HRSL3
- HRASLS3
- HREV107
- PLA2G16
- PLAAT-3
- H-REV107
- HREV107-1
- HREV107-3
- H-REV107-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.93 | ||
transcription factor perturbation | 0.88 | ||
virus perturbation | 0.72 | ||
gene perturbation | 0.71 | ||
small molecule perturbation | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 46.89 (req: < 5)
Gene RIFs: 16 (req: <= 3)
Antibodies: 290 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 46.89 (req: >= 5)
Gene RIFs: 16 (req: > 3)
Antibodies: 290 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 16
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (16)
Protein-Protein Interactions (92)
MIB2
Family: Enzyme
Novelty: 0.044378
p_int: 0.997683964
p_ni: 0.002316031
p_wrong: 6e-9
Data Source: BioPlex
Nearest Tclin Targets (5)
Upstream (2)
Downstream (3)
1 – 2 of 2
Pathways (61)
Reactome (8)
KEGG (8)
PathwayCommons (1)
WikiPathways (44)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Acyl chain remodelling of PC | ||||
Reactome | Acyl chain remodelling of PE | ||||
Reactome | Acyl chain remodelling of PI | ||||
Reactome | Acyl chain remodelling of PS | ||||
Reactome | Glycerophospholipid biosynthesis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Acyl chain remodelling of PC | ||||
Acyl chain remodelling of PE | ||||
Acyl chain remodelling of PI | ||||
Acyl chain remodelling of PS | ||||
Glycerophospholipid biosynthesis | ||||
Viral Interactions (0)
Gene Ontology Terms (26)
Functions (7)
Components (6)
Processes (13)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
uric acid measurement | 1 | 1 | 1 | 53.2 | |||||
urate measurement | 1 | 1 | 2 | 49.3 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
uric acid measurement | 1 | 53.2 | |||||
urate measurement | 2 | 49.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | phospholipase A2 group XVI | VGNC:13391 | 451279 | |||||
Macaque | phospholipase A2 group XVI | 722178 | ||||||
Mouse | MGI:2179715 | 225845 | ||||||
Rat | RGD:2829 | 24913 | ||||||
Dog | phospholipase A2 group XVI | 476045 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | phospholipase A2 group XVI | |||||
Macaque | phospholipase A2 group XVI | |||||
Mouse | ||||||
Rat | ||||||
Dog | phospholipase A2 group XVI | |||||
Publication Statistics
PubMed Score 46.89
PubMed score by year
PubTator Score 25.16
PubTator score by year
Related Publications
Text Mined References (30)
GeneRif Annotations (16)
Items per page:
0 of 0
PMID | Year | Title |
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