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Tbio
PLA2G15
Group XV phospholipase A2

Protein Summary
Description
Has transacylase and calcium-independent phospholipase A2 activity (PubMed:20410020, PubMed:23958596). Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid (PubMed:11790796, PubMed:25727495). Has high activity with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), catalyzing the transfer of oleic acid to N-acetyl-sphingosine. Required for normal phospholipid degradation in alveolar and peritoneal macrophages and in spleen (By similarity). May have weak lysophospholipase activity (PubMed:10092508). Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219345
  • ENSP00000219345
  • ENSG00000103066
  • ENST00000413021
  • ENSP00000394197

Symbol
  • LYPLA3
  • ACS
  • LLPL
  • LPLA2
  • LYPLA3
  • GXVPLA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.75
transcription factor perturbation
0.68
molecular function
0.67
small molecule perturbation
0.67
transcription factor binding site profile
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.31   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.31   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (91)
SCGB2A1
Tbio
Novelty:  0.01902973
p_int:  0.999989839
p_ni:  0.00000301
p_wrong:  0.000007151
Data Source:  BioPlex
PNPLA6
Tbio
Family:  Enzyme
Novelty:  0.00295195
Score:  0.916
Data Source:  STRINGDB
PLA2G10
Tchem
Family:  Enzyme
Novelty:  0.00289317
Score:  0.908
Data Source:  STRINGDB
PNPLA7
Tdark
Family:  Enzyme
Novelty:  0.11025485
Score:  0.904
Data Source:  STRINGDB
LCAT
Tchem
Family:  Enzyme
Novelty:  0.00307544
Score:  0.903
Data Source:  STRINGDB
GPCPD1
Tdark
Family:  Enzyme
Novelty:  0.03548168
Score:  0.9
Data Source:  STRINGDB
PLA2G1B
Tchem
Family:  Enzyme
Novelty:  0.00064842
Score:  0.899
Data Source:  STRINGDB
PLA2G3
Tbio
Family:  Enzyme
Novelty:  0.08997677
Score:  0.897
Data Source:  STRINGDB
PLA2G6
Tchem
Family:  Enzyme
Novelty:  0.00262569
Score:  0.888
Data Source:  STRINGDB
LYPLA1
Tchem
Family:  Enzyme
Novelty:  0.01217068
Score:  0.87
Data Source:  STRINGDB
Pathways (7)
Glycerophospholipid biosynthesis (R-HSA-1483206)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Hydrolysis of LPC
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Hydrolysis of LPC
Metabolism
Metabolism of lipids
Phospholipid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
2
2
3
91.8
glomerular filtration rate
4
3
3
6.4
77.8
high density lipoprotein cholesterol measurement
1
1
1
75
apolipoprotein A 1 measurement
1
1
1
73
metabolite measurement
1
1
1
70.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
3
91.8
glomerular filtration rate
3
6.4
77.8
high density lipoprotein cholesterol measurement
1
75
apolipoprotein A 1 measurement
1
73
metabolite measurement
1
70.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 group XV
VGNC:9098
454188
Macaque
phospholipase A2 group XV
702619
Mouse
MGI:2178076
192654
Rat
RGD:1302982
361401
Dog
phospholipase A2 group XV
VGNC:44621
403403
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 group XV
Macaque
phospholipase A2 group XV
Mouse
Rat
Dog
phospholipase A2 group XV
Publication Statistics
PubMed Score 65.31
PubMed score by year
PubTator Score 17.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title