Tbio PLA2G15 Group XV phospholipase A2

Protein Summary

Description

Has transacylase and calcium-independent phospholipase A2 activity (PubMed:20410020, PubMed:23958596). Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid (PubMed:11790796, PubMed:25727495). Has high activity with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), catalyzing the transfer of oleic acid to N-acetyl-sphingosine. Required for normal phospholipid degradation in alveolar and peritoneal macrophages and in spleen (By similarity). May have weak lysophospholipase activity (PubMed:10092508). Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8NCC3
• B3KMF3
• B4DUD1
• Q53GZ1
• Q9NPQ6
• Q9UG04
• Q9Y2B3

Gene Name

• PLA2G15

Ensembl ID

• ENST00000219345
• ENSP00000219345
• ENSG00000103066
• ENST00000413021
• ENSP00000394197

Symbol

• LYPLA3
• ACS
• LLPL
• LPLA2
• LYPLA3
• GXVPLA2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
metabolite	0.75
transcription factor perturbation	0.68
molecular function	0.67
small molecule perturbation	0.67
transcription factor binding site profile	0.65

Protein Classes

PANTHER Classes

Protein / Transferase / Acyltransferase / Group Xv Phospholipase A2

Protein / Hydrolase / Lipase / Phospholipase / Group Xv Phospholipase A2

DTO Classes

Protein / Enzyme / Hydrolase / Lipase / Phospholipase / Group Xv Phospholipase A2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.9   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 102   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.9   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0